Carver College of Medicine Events
ACB Seminar Series - Dr. Amy Ryan
Wednesday, September 9, 2026 9:30am to 10:30am
Dr. Amy Ryan, an Associate Professor of Anatomy and Cell Biology & Internal Medicine will present a seminar titled "Targeting IGFBP3 to Preserve Airway Stem Cell Function Following Genotoxic Injury."
REDCap MyCap Training
Wednesday, September 9, 2026 10:00am to 11:00am
This is the fifth step in the REDCap training series. In this training, we will discuss using the MyCap mobile app for data collection. We will cover features such as:
Creating participants
Creating tasks and schedules
Active tasks and their unique data output
Direct messages and announcements
This training is a demo and not hands-on. After this training, you will have a basic understanding of the MyCap mobile app for REDCap.
Register by clicking the virtual event link above or by going here: https:/...
Molecular Physiology and Biophysics Workshop, Adriana Della Pietra, PhD
Wednesday, September 9, 2026 12:00pm to 1:00pm
Iowa ReSpectacle Back to School Donation Drive
Wednesday, September 9 to Friday, September 25, 2026 (all day)
Donate used glasses to be recycled and redistributed across the globe during the back-to-school season! Drop-off locations are available from Aug. 24 to Sept. 25 across the University of Iowa campuses and clinics.
Neuroscience Interdisciplinary Program Thesis Defense Seminar: Avery Van De Water
Wednesday, September 9, 2026 1:00pm
Avery Van De Water is a PhD candidate in the Neuroscience Interdisciplinary Graduate Program. Their research has been conducted in Dorit Kliemann's laboratory.
If you are unable to attend in person, please consider showing your support and attending via Zoom. Please email britt-hokanson@uiowa.edu for the zoom link.
Recent Articles from the University of Iowa
Whole-exome sequencing in individuals with obsessive-compulsive disorder and chronic tic disorders identifies 36 large-effect risk genes
Wednesday, September 2, 2026
Obsessive-compulsive disorder (OCD) and chronic tic disorders (CTDs) are highly heritable. Rare mutations confer large risks for OCD and CTDs but only four high-confidence (hc) genes have been identified. Here we analyzed whole-exome sequencing data from 3,964 individuals with OCD, CTDs or both, including 2,418 trios. We found an excess in cases of de novo and rare protein-damaging mutations and identified 36 hc genes (false discovery rate < 0.1), including four previously identified hc genes...
B. burgdorferi infection alters synovial macrophage responses in a human ex vivo model of Lyme Arthritis
Wednesday, September 2, 2026
INTRODUCTION: Borrelia burgdorferi (Bb) infection can persist in protected sites like articular joints, presenting as migratory oligoarthritis characteristic of Lyme Arthritis (LA). LA is characterized by intermittent synovitis and joint swelling, but why acute infection is relapsing-remitting and not persistent remains unknown. We hypothesize that the immune response is unique to the joint space, particularly the response of Resident Synovial Macrophages (RSMs), and may be important in...
CD97/ADGRE5 attenuates the induction of adaptive type 2 immune responses in allergic asthma
Thursday, August 27, 2026
Allergic asthma results from an uncontrolled type 2 immune response to inhaled allergens. Here, we investigate the function of CD97/ADGRE5, expressed in mouse and human immune and lung epithelial cells, in this disease. Female Cd97^(-/-) mice exhibit an exacerbated asthmatic phenotype across multiple models, primarily due to CD97 loss on immune cells. A single CD97 antibody treatment before allergen sensitization worsens allergic responses, highlighting a role for CD97 in early immune...
Secreted nuclease effector neutralization by active site mimicry in Bacillota
Monday, August 17, 2026
Polymorphic toxins mediate interbacterial antagonism among competitors in the gut microbiome. Nuclease effectors, distantly related to the type VI-secreted Bacteroidales Tde, are enriched in human gut Bacillota. Tde mediates antagonism among Bacillota, and expression of the cognate immunity, Tdi, in recipients is protective. Crystal structures of Tde/Tdi complexes from two Bacillus spp. and Enterococcus quebecensis highlight a conserved mechanism of immunity. Tdi engages Tde with high-affinity,...
Distinct immunomodulatory effects of synthetic progestins compared with natural progesterone in human immune cells
Monday, August 17, 2026
Progesterone exerts important immunomodulatory functions, yet the immune effects of structurally diverse synthetic progestins remain incompletely defined. Given their variable receptor-binding profiles and links to altered inflammatory outcomes, we examined how commonly used progestins regulate immune signaling in primary human cells. Peripheral blood mononuclear cells from healthy female donors were exposed to physiologically relevant concentrations of natural progesterone (P4) and...
MERS-CoV in the Middle East and Africa: from surveillance gaps in humans and dromedary camels to One Health frameworks for spillover, prevention, research and response preparedness
Saturday, August 15, 2026
Middle East respiratory syndrome coronavirus (MERS-CoV) remains a low-incidence but high-consequence zoonotic coronavirus threat. Since its identification in Saudi Arabia in 2012, more than 2600 laboratory-confirmed cases have been reported from 27 countries, most from the Arabian Peninsula; the reported case fatality ratio is high but probably overestimates infection fatality because mild and asymptomatic infections are under-detected. Dromedary camels across the Middle East, North Africa, East...
Influenza
Thursday, August 6, 2026
Influenza A and B viruses are considerable public health threats. Annual seasonal epidemics are driven by antigenic drift and cause an estimated 3-5 million severe cases and 290,000-650,000 deaths annually. The clinical presentation of seasonal influenza is typically an abrupt, uncomplicated acute respiratory illness with full recovery; however, it can lead to severe, life-threatening complications in individuals at high risk. Antigenic shift caused by reassortment of a seasonal influenza A...
Sex-specific outcomes following chorioamnionitis
Tuesday, July 28, 2026
Chorioamnionitis is a common cause of perinatal inflammation and is associated with adverse neonatal and long-term outcomes. Although male infants experience higher rates and greater severity of many inflammation-related morbidities, the contribution of fetal sex to chorioamnionitis-related outcomes remains understudied. This review synthesizes evidence from human studies and animal models to evaluate how sexually dimorphic placental biology and fetal immune responses shape offspring...
Global, regional, and national burden of road injuries 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023
Monday, July 20, 2026
BACKGROUND: Road injuries are a leading cause of mortality and morbidity worldwide. Years of international efforts have aimed to strengthen policy engagement, including the 2020 UN General Assembly's proclamation of the Second Decade of Action for Road Safety (2021-30), targeting a 50% reduction in road traffic deaths and serious injuries by 2030. The aim of this study is to provide estimates to monitor progress and identify intervention gaps.
Innate Immune Cell and Epithelial Subsets Coordinate Airway Responses to Allergen
Thursday, July 16, 2026
CONCLUSION: Allergen challenge promotes diverse pro-inflammatory transcriptional responses in the airways, and MCs, basophils, and AECs play distinct but critical roles in coordinating this response. However, airway responses to allergen may vary considerably based on the baseline airway inflammatory endotype.