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Carver College of Medicine Events

Pain Research Program Presentation - Jamie Morton, PhD

Wednesday, December 6, 2023 9:00am to 10:00am
Medical Education Research Facility
"Concurrent Use of TENS and Buprenorphine for Opioid Use Disorder Treatment" Presented by Jamie Morton, PhD, RN Postdoctoral Research Scholar in Dr. Barbara St. Marie's lab

ACB Seminar Series - Ling Yang

Wednesday, December 6, 2023 11:00am to 12:00pm
Bowen Science Building
Dr. Ling Yang from the Anatomy and Cell Biology Department will present a seminar titled "Shaping Immuno-Metabolic Homeostasis by the Lysosome."

Biochemistry and Molecular Biology Undergraduate Honors Presentations

Thursday, December 7, 2023 10:30am to 11:20am
Medical Education Research Facility
BMindful Holy Days: Buddha's Enlightenment Day (Buddhism) promotional image

BMindful Holy Days: Buddha's Enlightenment Day (Buddhism)

Friday, December 8, 2023 (all day)
University of Iowa Division of Diversity, Equity, and Inclusion
BMindful is an initiative that seeks to meet the needs of diverse communities by providing event and conference planners with the dates of holy days of major religious faiths for five years into the future. By providing these dates in advance, BMindful seeks to help planners avoid those dates when scheduling events. BMindful does not include all religious holy days. It focuses on three major holy days for each faith—days when faith members may choose not to go to work or send their children to...

Women In Micro & Immuno Coffee Hour

Monday, December 11, 2023 11:00am to 12:00pm
Carver Biomedical Research Building
Join us for the Women in Micro & Immuno Coffee Hour. It is the monthly coffee hour on the third Monday of the month from 11 a.m. to noon in 1289 CBRB. Enjoy coffee, pastries and contribute to the discussion! This is open to all—students, staff, postdocs, and faculty interested in promoting women in science (we have several male faculty in regular attendance and we appreciate the support!). Speakers change monthly. Contact: jessica-tucker@uiowa.edu for details.
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Recent Articles from the University of Iowa

Th1/17 polarization and potential treatment by an anti-interferon-γ DNA aptamer in Hunner-type interstitial cystitis

Wednesday, November 29, 2023
Yoshiyuki Akiyama
Hunner-type interstitial cystitis (HIC) is a rare, enigmatic inflammatory disease of the urinary bladder with no curative treatments. In this study, we aimed to characterize the unique cellular and immunological factors specifically involved in HIC by comparing with cystitis induced by Mycobacterium bovis bacillus Calmette-Guérin, which presents similar clinicopathological features to HIC. Here, we show that T helper 1/17 +polarized immune responses accompanied by prominent overexpression of...

Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2',5,5'-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats

Thursday, November 23, 2023
Hui Wang
Polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) that ubiquitously exist in the environment. PCB exposure has been linked to cancer and multi-system toxicity, including endocrine disruption, immune inhibition, and reproductive and neurotoxicity. 2,2',5,5'-Tetrachlorobiphenyl (PCB 52) is one of the most frequently detected congeners in the environment and human blood. The hydroxylated metabolites of PCB 52 may also be neurotoxic, especially for children whose brains are...

Identification of host essential factors for recombinant AAV transduction of the polarized human airway epithelium

Wednesday, November 15, 2023
Siyuan Hao
The essential steps of successful gene delivery by recombinant adeno-associated viruses (rAAVs) include vector internalization, intracellular trafficking, nuclear import, uncoating, double-stranded (ds)DNA conversion, and transgene expression. rAAV2.5T has a chimeric capsid of AAV2 VP1u and AAV5 VP2 and VP3 with the mutation A581T. Our investigation revealed that KIAA0319L, the multiple AAV serotype receptor, is not essential for vector internalization but remains critical for efficient vector...

Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis

Wednesday, November 15, 2023
Jiaqing Hao
One of the hallmarks of intractable psoriasis is neutrophil infiltration in skin lesions. However, detailed molecular mechanisms of neutrophil chemotaxis and activation remain unclear. Here, we demonstrate a significant upregulation of epidermal fatty acid binding protein (E-FABP, FABP5) in the skin of human psoriasis and psoriatic mouse models. Genetic deletion of FABP5 in mice by global knockout and keratinocyte conditional (Krt6a-Cre) knockout, but not myeloid cell conditional (LysM-Cre)...

3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex

Tuesday, November 14, 2023
Zer Vue
During aging, muscle gradually undergoes sarcopenia, the loss of function associated with loss of mass, strength, endurance, and oxidative capacity. However, the 3D structural alterations of mitochondria associated with aging in skeletal muscle and cardiac tissues are not well described. Although mitochondrial aging is associated with decreased mitochondrial capacity, the genes responsible for the morphological changes in mitochondria during aging are poorly characterized. We measured changes in...

Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma

Thursday, November 9, 2023
Selene Clay
CONCLUSION: We report novel associations between rare variants in genes and allergic and inflammatory phenotypes in children with diverse ancestries, highlighting TNFRSF21 as contributing to the development of allergic asthma.

Purification, characterization, and cloning of a novel pro-inflammatory secreted protein from <em>Staphylococcus aureus</em>

Wednesday, November 8, 2023
Patrick M Schlievert
Staphylococcus aureus is a human pathogen, causing infections ranging from benign skin and soft tissue infections to life-threatening pneumonia, sepsis/infective endocarditis, and toxic shock syndrome (TSS). The organisms cause infections through production of both cell-surface and secreted virulence factors. We focus primarily on secreted virulence factors, having done scans for such proteins for many years. We have purified and characterized TSS toxin-1; staphylococcal enterotoxin-like...

Human lysyl-tRNA synthetase phosphorylation promotes HIV-1 proviral DNA transcription

Tuesday, November 7, 2023
Yingke Tang
Human lysyl-tRNA synthetase (LysRS) was previously shown to be re-localized from its normal cytoplasmic location in a multi-aminoacyl-tRNA synthetase complex (MSC) to the nucleus of HIV-1 infected cells. Nuclear localization depends on S207 phosphorylation but the nuclear function of pS207-LysRS in the HIV-1 lifecycle is unknown. Here, we show that HIV-1 replication was severely reduced in a S207A-LysRS knock-in cell line generated by CRISPR/Cas9; this effect was rescued by S207D-LysRS. LysRS...

Pilot study of HER2 targeted 64 Cu-DOTA-tagged PET imaging in gastric cancer patients

Monday, October 30, 2023
Matthew C Hernandez
CONCLUSION: Despite the potential of 64 Cu-DOTA-trastuzumab PET imaging of HER2+ metastatic breast cancer, a 5 mg dose of this radiotracer injected 24-48 h before imaging was insufficient to identify HER2+ GC. These results inform future GC imaging studies to optimize biomarker-targeted therapies based on dosage and timing for more clinically relevant imaging.

Intronic Germline <em>DICER1</em> Variants in Patients With Sertoli-Leydig Cell Tumor

Thursday, October 26, 2023
Claudette R Fraire
Germline pathogenic loss-of-function (pLOF) variants in DICER1 are associated with a predisposition for a variety of solid neoplasms, including pleuropulmonary blastoma and Sertoli-Leydig cell tumor (SLCT). The most common DICER1 pLOF variants include small insertions or deletions leading to frameshifts, and base substitutions leading to nonsense codons or altered splice sites. Larger deletions and pathogenic missense variants occur less frequently. Identifying these variants can trigger...