Carver College of Medicine Events
Pain Interest Group Workshop - Adriana Della Pietra, PhD
Wednesday, February 11, 2026 9:00am to 10:00am
Comparison of Phyto- and Endocannabinoid Effects in Migraine Models
Adriana Della Pietra, PhD
Postdoctoral Researcher in Dr. Andrew Russo's Lab
ACB Seminar Series - Dr. Pierre Coulombe
Wednesday, February 11, 2026 9:30am to 10:30am
Dr. Pierre Coulombe, Professor and Chair of the Department of Cell and Developmental Biology from the University of Michigan, will present a seminar titled "Sequential Expression of Keratins Regulate Progenitor and Differentiating Keratinocytes in Healthy and Diseased Skin."
Association of Multicultural Scientists (AMS) Annual Comprehensive Exam Panel
Thursday, February 12, 2026 10:00am to 12:00pm
We are the Association of Multicultural Scientists (AMS), a student organization based in the Carver College of Medicine dedicated to fostering connection, community, and support among scientists. Our diverse membership includes undergraduate students, graduate students, postdoctoral fellows, and research staff, all united by a shared commitment to mentorship, inclusion, and scientific excellence.
We will be hosting our 📓 Annual Comprehensive Exam Panel ✏️will take place on Thursday, February...
Internal Medicine Grand Rounds 2/12/2026
Thursday, February 12, 2026 12:00pm to 1:00pm
"CPC: A Case of Disseminated Histo" by Katrina Soyangco. MD and Michael Olthoff, MD
Biomedical & Health Informatics Community Meeting
Thursday, February 12, 2026 12:00pm to 1:00pm
We have established a community of CCOM Informaticists who are applying these skills in their work at UIHC. You are invited to join us during our monthly seminar presentations.
Recent Articles from the University of Iowa
A Quantitative Lung Mucin Score to Identify Chronic Bronchitis
Tuesday, January 27, 2026
CONCLUSIONS: The MUCQ metric was superior in distinguishing patients with CB compared to a total mucin concentration. Trials are needed to ascertain the prospective use of MUCQ metrics in research and clinical settings for assessment, management, and tracking therapeutic responses in CB and potentially other muco-obstructive conditions. (Funded by the National Institutes of Health and others.).
Immortalization and characterization of Schwann cell lines derived from NF1-associated cutaneous neurofibromas
Wednesday, January 21, 2026
Neurofibromatosis type 1 (NF1) is an autosomal dominant condition in which patients are heterozygous for a disruptive pathogenic variant in the NF1 gene. The most characteristic feature of the condition NF1 is the neurofibroma, a benign, multi-cellular tumor which initiates when a cell of the Schwann cell lineage gains a somatic pathogenic variant of the other NF1 allele. Neurofibromas developing at nerve termini in the skin are termed "cutaneous" neurofibromas (cNFs), while those developing...
Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review
Tuesday, January 20, 2026
Asthma is a heterogeneous disease characterized by chronic airway inflammation and reversible airflow obstruction. Particularly in severe asthma, airway mucus plugs can contribute to substantial and persistent airflow obstruction, despite inhaled corticosteroid and bronchodilator treatment. Consequently, it is important that clinicians assess and treat mucus plugs. Increased mucus production and airway eosinophilia caused by type 2 (T2) inflammation contributes to mucus plug formation and...
Aroclor 1254 inhibits anti-inflammatory macrophage polarization through an AhR-dependent mechanism
Friday, January 16, 2026
Macrophages are critical regulators of tissue homeostasis and inflammation. During the development of chronic inflammatory diseases, tissue-resident macrophages often shift from an anti-inflammatory (M2) to a pro-inflammatory (M1) phenotype. Understanding the factors that drive this polarization shift is essential for elucidating the mechanisms underlying diseases such as cancer, cardiovascular disease, and metabolic syndrome. Environmental toxicants, including polychlorinated biphenyls (PCBs),...
Metastatic Uveal Melanoma Surveillance: A Delphi Panel Consensus
Saturday, January 10, 2026
CONCLUSIONS: This is the first study to provide consensus-based guidance incorporating GEP and PRAME status into surveillance recommendations for uveal melanoma, offering a standardized framework to guide clinical practice and future research.
Anti-IL-15 treatment reduces acute lentivirus inflammation and signaling in the brain
Saturday, January 10, 2026
HIV-associated neurocognitive disorder (HAND) remains a significant complication in people living with HIV, with inflammation playing a central role in its pathogenesis. Understanding how the brain's immune network responds to lentiviral infection is therefore critical. We show that acute simian immunodeficiency virus (SIV) infection elicits a robust resident brain immune response in control animals, marked by enhanced microglial ramification. In contrast, animals pretreated with...
Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection
Wednesday, January 7, 2026
Post-acute sequelae of COVID-19 (PASC) encompasses persistent neurological disease, including olfactory and cognitive dysfunction. The basis for this dysfunction is poorly understood. Here, we report neurological dysfunction for at least 120 d postinfection in mice infected with a virulent nonneurotropic mouse-adapted SARS-CoV-2. Long after recovery from nasal infection, we observed diminished tyrosine hydroxylase expression in olfactory bulb glomeruli and in substantia nigra. Similar changes...
Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming
Saturday, January 3, 2026
Pulmonary group 2 innate lymphoid cells (ILC2s) are key drivers of Type 2 inflammation in diseases like asthma, yet the molecular mechanisms regulating their function are incompletely understood. Using the genetically diverse Collaborative Cross (CC) mouse panel, we mapped a quantitative trait locus (QTL) that governs ILC2 prevalence in the lung after aeroallergen exposure. This QTL induces a large population of ILC2s in the lung that are resistant to activation and have diminished Type 2...
Interferons Inhibit Ebola Virus Infection of Human Keratinocytes
Wednesday, December 31, 2025
Orthoebolavirus zairense is the species name for Zaire Ebola virus (EBOV) within Filoviridae. This group of viruses can cause severe disease in humans, characterized by hemorrhagic shock, coagulation abnormalities, and severe inflammation. While tissue macrophages are critical targets early during EBOV infection, other cell types support viral replication as disease progresses. At late stages of infection, infectious EBOV is found on the surface of the skin, which may be a critical source of...
Human macrophages release exosomes containing anti-inflammatory microRNAs after phagocytosis of Leishmania infantum
Friday, December 26, 2025
INTRODUCTION: The protozoan Leishmania infantum causes visceral leishmaniasis, a disease associated with suppressed systemic innate and adaptive immune responses. Mechanisms underlying the generalized immune suppression are incompletely understood. Exosomes are a subset of microvesicles released from eukaryotic cells, which contain proteins, lipids, and nucleic acids, including microRNAs (miRNAs). These small regulatory RNAs can simultaneously modify the expression of many genes and pathways. We...