Carver College of Medicine Events
Molecular Physiology and Biophysics Seminar - Eric Gibbs
Tuesday, September 17, 2024 9:30am to 10:30am
Eric Gibbs is a Postdoctoral Scholar at Case Western Reserve University in the Department of Pharmacology in Cleveland, Ohio. He will present a seminar entitled, "Modulation of Glycine Receptors by Orthosteric and Allosteric Ligands"
REDCap Advanced Training
Tuesday, September 17, 2024 10:00am to 11:00am
This is the fourth step in the REDCap training series. In this training, we will cover advanced features such as:
• Importing data from csv
• Ways to customize your data entry experience with form display logic
• Making your forms more dynamic and personalized with context aware smart variables
• Sending automated, conditional email alerts
• Ensuring data is high quality by executing data quality rules, creating data missingness codes, and opening data queries
• And more
This training is a demo and not hands-on. After this training, you will have an advanced understanding of REDCap.
Register by clicking the virtual event link above or by going here: https://redcap.link/icts_training
Neuroscience & Pharmacology Postdoctoral Seminar Series - Laurel Seemiller, PhD
Tuesday, September 17, 2024 10:30am to 11:30am
"Uncovering the role of the neuropeptide, somatostatin, in sexually divergent behavioral consequences of adolescent binge drinking"
Presented by Laurel Seemiller, PhD
Postdoctoral Scholar
Department of Biology
Pennsylvania State University
Biochemistry and Molecular Biology Research Workshop
Tuesday, September 17, 2024 12:30pm to 1:20pm
More information forthcoming.
Microbiology and Immunology Seminar: Wenhan Zhu, PhD
Tuesday, September 17, 2024 3:00pm to 4:00pm
Commensal iron acquisition modifies host nutritional immunity during Salmonella infection
Wenhan Zhu, PhD
Assistant Professor, Vanderbilt University Medical Center
Recent Articles from the University of Iowa
Discovery of CO<sub>2</sub> tolerance genes associated with virulence in the fungal pathogen Cryptococcus neoformans
Wednesday, September 4, 2024
Cryptococcus neoformans is a ubiquitous soil fungus and airborne pathogen that causes over 180,000 deaths each year. Cryptococcus must adapt to host CO(2) levels to cause disease, but the genetic basis for this adaptation is unknown. We utilized quantitative trait loci mapping with 374 progeny from a cross between a CO(2)-tolerant clinical isolate and a CO(2)-sensitive environmental isolate to identify genetic regions regulating CO(2) tolerance. To identify specific quantitative trait genes, we...
Determinants of pegivirus persistence, cross-species infection, and adaptation in the laboratory mouse
Wednesday, August 28, 2024
Viruses capable of causing persistent infection have developed sophisticated mechanisms for evading host immunity, and understanding these processes can reveal novel features of the host immune system. One such virus, human pegivirus (HPgV), infects ~15% of the global human population, but little is known about its biology beyond the fact that it does not cause overt disease. We passaged a pegivirus isolate of feral brown rats (RPgV) in immunodeficient laboratory mice to develop a mouse-adapted...
Pan-beta-coronavirus subunit vaccine prevents SARS-CoV-2 Omicron, SARS-CoV, and MERS-CoV challenge
Tuesday, August 27, 2024
Three highly pathogenic coronaviruses (CoVs), SARS-CoV-2, SARS-CoV, and MERS-CoV, belonging to the genus beta-CoV, have caused outbreaks or pandemics. SARS-CoV-2 has evolved into many variants with increased resistance to the current vaccines. Spike (S) protein and its receptor-binding domain (RBD) fragment of these CoVs are important vaccine targets; however, the RBD of the SARS-CoV-2 Omicron variant is highly mutated, rending neutralizing antibodies elicited by ancestral-based vaccines...
Restoration of TFPI2 by LSD1 inhibition suppresses tumor progression and potentiates antitumor immunity in breast cancer
Sunday, August 18, 2024
Histone lysine-specific demethylase 1 (LSD1) is frequently overexpressed in triple negative breast cancer (TNBC), which is associated with worse clinical outcome in TNBC patients. However, the underlying mechanisms by which LSD1 promotes TNBC progression remain to be identified. We recently established a genetically engineered murine model by crossing mammary gland conditional LSD1 knockout mice with Brca1-deficient mice to explore the role of LSD1 in TNBC pathogenesis. Cre-mediated Brca1 loss...
The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis
Thursday, August 15, 2024
A disturbed balance between excitation and inhibition (E/I balance) is increasingly recognized as a key driver of neurodegeneration in multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system. To understand how chronic hyperexcitability contributes to neuronal loss in MS, we transcriptionally profiled neurons from mice lacking inhibitory metabotropic glutamate signaling with shifted E/I balance and increased vulnerability to inflammation-induced neurodegeneration....
Interleukin-2 family cytokines IL-9 and IL-21 differentially regulate innate and adaptive type 2 immunity in asthma
Thursday, August 15, 2024
CONCLUSION: IL-9 and IL-21 play important and non-redundant roles in allergic asthma by boosting ILC2s and T(H)2 cells, revealing a dual IL-9 and IL-21 targeting strategy as a new and testable approach.
Antibody characterization is critical to enhance reproducibility in biomedical research
Wednesday, August 14, 2024
Antibodies are used in many areas of biomedical and clinical research, but many of these antibodies have not been adequately characterized, which casts doubt on the results reported in many scientific papers. This problem is compounded by a lack of suitable control experiments in many studies. In this article we review the history of the 'antibody characterization crisis', and we document efforts and initiatives to address the problem, notably for antibodies that target human proteins. We also...
Game of microbes: the battle within - gut microbiota and multiple sclerosis
Thursday, August 8, 2024
Multiple sclerosis (MS) is a chronic and progressive autoimmune disease of the central nervous system (CNS), with both genetic and environmental factors contributing to the pathobiology of the disease. While human leukocyte antigen (HLA) genes have emerged as the strongest genetic factor, consensus on environmental risk factors are lacking. Recently, trillions of microbes residing in our gut (microbiome) have emerged as a potential environmental factor linked with the pathobiology of MS as PwMS...
Transcriptomic classification of diffuse large B-cell lymphoma identifies a high-risk activated B-cell-like subpopulation with targetable MYC dysregulation
Thursday, August 8, 2024
Immunochemotherapy has been the mainstay of treatment for newly diagnosed diffuse large B-cell lymphoma (ndDLBCL) yet is inadequate for many patients. In this work, we perform unsupervised clustering on transcriptomic features from a large cohort of ndDLBCL patients and identify seven clusters, one called A7 with poor prognosis, and develop a classifier to identify these clusters in independent ndDLBCL cohorts. This high-risk cluster is enriched for activated B-cell cell-of-origin, low immune...
<em>Pseudomonas aeruginosa</em> surface motility and invasion into competing communities enhance interspecies antagonism
Tuesday, August 6, 2024
Chronic polymicrobial infections involving Pseudomonas aeruginosa and Staphylococcus aureus are prevalent, difficult to eradicate, and associated with poor health outcomes. Therefore, understanding interactions between these pathogens is important to inform improved treatment development. We previously demonstrated that P. aeruginosa is attracted to S. aureus using type IV pili (TFP)-mediated chemotaxis, but the impact of attraction on S. aureus growth and physiology remained unknown. Using live...