Carver College of Medicine Events
Sioux City Mini Medical School – Beyond the Bump: Latest in Maternal, Fetal, and Neonatal Medicine
Wednesday, November 5, 2025 5:15pm to 7:30pm
Exploring how maternal, fetal, and neonatal medicine affects everyone’s health
Maternal and fetal medicine isn’t just for babies. Pregnancy and birth outcomes affect everyone’s health. Join us for an educational event to explore the latest from Iowa’s research leaders and how advancements in maternity care and neonatal medicine support critical health needs in our state.
This evening program will help you understand pre-eclampsia, fetal movement monitoring, and how the neonatal immune system...
Apply for Innovation Challenge Pitch Competition Fall 2025
Thursday, November 6, 2025 (all day)
Innovation Challenge is a university-wide competition with the goal to identify, advance and support the most innovative and entrepreneurial projects on campus.
Molecular Physiology and Biophysics Workshop, Sandipan Chowdhury, PhD
Thursday, November 6, 2025 9:30am to 10:30am
REDCap Surveys Training
Thursday, November 6, 2025 10:00am to 11:00am
This is the third step in the REDCap training series. In this training, we will cover survey configuration and distribution such as:
Allowing potential participants to self-initiate participation in your study with public surveys Manually and automatically sending surveys Administering electronic consent (e-consent) forms Controlling survey access with conditional logic and survey loginThis training is a demo and not hands-on. After this training you will have a basic understanding of...
Hardin Open Workshops - ORCiD: Open Researcher and Contributor ID (Zoom)
Thursday, November 6, 2025 11:00am to 12:00pm
What is ORCID? Why would you want one? This session will discuss ORCID, how researchers can benefit from having one, and how ORCID connects with other information systems. This will also be a hands-on workshop where everyone will have the chance to create their own ORCID and learn the most efficient ways to populate their profile with their publications.
PLEASE NOTE
Class will be taught via Zoom. Advance registration is required. Registrants will be emailed the Zoom link 30 minutes before the...
Recent Articles from the University of Iowa
Atopic dermatitis, primary atopic disorders, and the cutaneous microbiome: current understanding of an expanding field
Monday, November 3, 2025
Atopic dermatitis is a common inflammatory skin disease with rapidly expanding worldwide prevalence. Increasingly, cases of severe and early-onset dermatitis have been identified and found to be due to underlying monogenic mutations, leading to immune dysregulation. These conditions, called primary atopic disorders, have become an area of extensive study over the last 30 years. Simultaneously, our understanding of the human microbiome has steadily grown, and there is clear evidence that...
The <em>Candida albicans</em> transcription factor Efg1 governs hyphal morphogenesis independently of the cAMP-protein kinase A pathway
Friday, October 31, 2025
Candida albicans is one of the most common causes of human fungal disease. An intensively studied C. albicans virulence traits is its ability to adopt both yeast and filamentous morphologies. Accordingly, the regulation of the yeast-to-filament transition has been an area of intense study in medical mycology. A long-standing mechanistic paradigm in this field is that the cAMP-protein kinase A pathway phosphorylates a master transcriptional regulator of C. albicans filamentation, Efg1, to drive...
T<sub>H</sub>1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata
Friday, October 31, 2025
Alopecia areata (AA) is an autoimmune disease defined by hair loss and peribulbar infiltrate of CD8 and CD4 T cells. Prior studies have focused on the role of CD8 T cells in the development of AA. Multiple roles for CD4 T cell help have been demonstrated for support of CD8 T cell responses; however, the role of CD4 T cells in AA remains unclear. Here, we demonstrate that CD4 T cells from the skin-draining lymph nodes (SDLNs) of AA mice transferred disease to recipient mice. These cells exhibited...
Quantifying Nuance within Sepsis-Associated Immune Suppression toward Diagnostic Certainty
Thursday, October 30, 2025
Impact of sepsis on human T-cell function and outcome was assessed. In sepsis survivors, IFNγ-production in response to T-cell stimulation remains intact, while sepsis non-survivors display exaggerated IFNγ responses to TCR-independent stimuli.
ACE2-Mediated Infection of Immortalized Human Visceral Adipocytes by SARS-CoV-2
Wednesday, October 29, 2025
Adipocytes can be infected by SARS-CoV-2, potentially contributing to the obesity-associated severity of COVID-19. Circumstantial evidence points to angiotensin-converting enzyme 2 (ACE2) as the necessary receptor for adipocyte infection, but this has not been demonstrated experimentally. Using differentiated immortalized human preadipocyte lines that we developed, we found that visceral adipocytes express higher levels of ACE2 and are more susceptible to SARS-CoV-2 spike (S)-mediated...
iPSC-derived ITGA6-positive cells restore aqueous humor outflow in glaucoma eyes
Tuesday, October 28, 2025
Decreased trabecular meshwork (TM) cellularity is a critical pathogenic cause of primary open-angle glaucoma, yet therapies to regenerate the decellularized TM are very limited. Induced pluripotent stem cell-derived TM-like cells (iPSC-TM) can efficiently restore aqueous humor outflow. Here, we conducted a multi-modal RNA sequencing analysis to characterize the molecular mechanisms underlying TM regeneration. Our clustering analysis identified a group of iPSC-derived alpha6 integrin-positive...
Neutrophils are key modulators of sex differences in LPS-induced shock in mice
Tuesday, October 28, 2025
Lipopolysaccharide (LPS) exposure in mice induces robust morbidity and mortality, and is widely used as a model for sepsis. However, the role of biological sex in modulating immune responses during LPS-induced sepsis remains incompletely understood. In this study, we investigated how sex influences immune responses following LPS challenge in mice. Using age-matched mice, we found that during primary LPS challenge, females exhibited significantly higher mortality than males. This difference...
Prostaglandin D2 axis impairs immunity against melanoma via dendritic cells and γδ T cells in middle-aged mice
Tuesday, October 28, 2025
The risk of developing melanoma increases with age. Although immune checkpoint blockade (ICB) therapy has shown considerable success, a significant portion of melanoma patients either fail to respond to ICB or eventually develop resistance. This leads to the urgent need for exploring novel treatments. Phospholipase A2 group IID (PLA2G2D) is an inducible enzyme found in myeloid cells, especially in aging dendritic cells (DCs), that exert an immunosuppressive effect by producing anti- or...
Inflammasome targeting for periodontitis prevention is sex dependent
Monday, October 27, 2025
Inflammasome initiates inflammation via the maturation of interleukin-1 beta (IL-1β). Periodontitis is a prevalent, male-biased disease characterized by inflammation-driven bone loss, yet the mechanism(s) of this sex bias is unknown. This study explored whether enhanced inflammasome represents a causal mechanism for this bias. Analyses of three separate human studies (>6,200 samples) show that males have significantly higher IL-1β in the gingival crevicular fluid than females during health and...
Case Report: Novel <em>IL10RB</em> variant causing very early onset-inflammatory bowel disease
Wednesday, October 22, 2025
CONCLUSION: We report a novel, loss-of-function IL10RB variant causing VEO-IBD, thus expanding the genotypic spectrum of this condition. This case highlights the diagnostic and therapeutic challenges of IL-10R deficiency-related VEO-IBD. It also underscores the importance of early recognition of monogenic causes of IBD, use of interim immunomodulatory therapies, and the need for optimal timing and donor selection for HSCT.