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Dissertation Camp promotional image

Dissertation Camp

Tuesday, May 28, 2024 9:00am to 1:00pm
Virtual
The 2024 dissertation writing camp for graduate students
Dissertation Camp promotional image

Dissertation Camp

Wednesday, May 29, 2024 9:00am to 1:00pm
Virtual
The 2024 dissertation writing camp for graduate students

TriNetX Basic Training

Thursday, May 30, 2024 9:00am to 10:00am
Virtual
This training will provide an in-depth look at TriNetX and show you how to use the tool. We will go through building a study, searching for a specific population, and finally what information you can gather from the specific cohort. We will also discuss next steps on getting data extracted for research. After this training you will have a thorough understanding of how to use TriNetX and what the process is to get data extracted for research studies. Register by clicking the virtual event link...
Dissertation Camp promotional image

Dissertation Camp

Thursday, May 30, 2024 9:00am to 1:00pm
Virtual
The 2024 dissertation writing camp for graduate students

Internal Medicine Grand Rounds

Thursday, May 30, 2024 12:00pm to 1:00pm
General Hospital
"CPC: Fentanyl" by Carlie Sorensen, MD, 1st Year Resident, Internal Medicine; Dan McCabe, MD, Clinical Associate Professor of Emergency Medicine; Anna Merrill, MD, Clinical Associate Professor of Pathology; Matthew Krasowski, MD, Clinical Professor of Pathology; and Dennis Firchau, MD, Clinical Associate Professor of Pathology.
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Recent Articles from the University of Iowa

Molecular characterization of human astrovirus infection in children under 5 years of age with acute gastroenteritis in Tehran, Iran, 2021-2022: co-infection with rotavirus

Tuesday, May 14, 2024
Atefeh Kachooei
Human astroviruses (HAstVs) are considered important causative pathogens of acute gastroenteritis (AGE) in children under 5 years of age worldwide, along with group A rotavirus (RVA), norovirus (NoV), and enteric adenovirus (EAdV). The present study was aimed to both detect HAstV and its co-infections and investigate genetic analysis of circulating HAstV and co-infected virus in hospitalized children under 5 years of age with AGE in Iran. Accordingly, a sum of 200 stool specimens were screened...

Serious neurological adverse events in immunocompetent children and adolescents caused by viral reactivation in the years following varicella vaccination

Wednesday, April 24, 2024
Prashanth Ramachandran
Serious adverse events following vaccination include medical complications that require hospitalisation. The live varicella vaccine that was approved by the Food and Drug Administration in the United States in 1995 has an excellent safety record. Since the vaccine is a live virus, adverse events are more common in immunocompromised children who are vaccinated inadvertently. This review includes only serious adverse events in children considered to be immunocompetent. The serious adverse event...

A panel of recombinant <em>Leishmania donovani</em> cell surface and secreted proteins identifies LdBPK_323600.1 as a serological marker of symptomatic infection

Friday, April 19, 2024
Adam J Roberts
Visceral leishmaniasis is a deadly infectious disease and is one of the world's major neglected health problems. Because the symptoms of infection are similar to other endemic diseases, accurate diagnosis is crucial for appropriate treatment. Definitive diagnosis using splenic or bone marrow aspirates is highly invasive, and so, serological assays are preferred, including the direct agglutination test (DAT) or rK39 strip test. These tests, however, are either difficult to perform in the field...

Disruption of IFNgamma, GZMB, PRF1, or LYST Results in Reduced Suppressive Function in Human CD8+ T Cells

Friday, April 12, 2024
Chakrapani Vemulawada
An imbalance between proinflammatory and regulatory processes underlies autoimmune disease pathogenesis. We have shown that acute relapses of multiple sclerosis are characterized by a deficit in the immune suppressive ability of CD8+ T cells. These cells play an important immune regulatory role, mediated in part through cytotoxicity (perforin [PRF]/granzyme [GZM]) and IFNγ secretion. In this study, we further investigated the importance of IFNγ-, GZMB-, PRF1-, and LYST-associated pathways in...

Single-molecule epitranscriptomic analysis of full-length HIV-1 RNAs reveals functional roles of site-specific m<sup>6</sup>As

Thursday, April 11, 2024
Alice Baek
Although the significance of chemical modifications on RNA is acknowledged, the evolutionary benefits and specific roles in human immunodeficiency virus (HIV-1) replication remain elusive. Most studies have provided only population-averaged values of modifications for fragmented RNAs at low resolution and have relied on indirect analyses of phenotypic effects by perturbing host effectors. Here we analysed chemical modifications on HIV-1 RNAs at the full-length, single RNA level and nucleotide...

The Impact of High Adiposity on Endometrial Progesterone Response and Metallothionein Regulation

Wednesday, April 10, 2024
Alina R Murphy
CONCLUSIONS: Taken together, the in vitro and in vivo systems used here revealed that high adiposity or obesity can alter MT expression by decreasing progesterone response in the epithelial cells and increasing oxidative stress in the stroma.

Severity of Respiratory Syncytial Virus vs COVID-19 and Influenza Among Hospitalized US Adults

Thursday, April 4, 2024
Diya Surie
CONCLUSIONS AND RELEVANCE: Among adults hospitalized in this US cohort during the 16 months before the first RSV vaccine recommendations, RSV disease was less common but similar in severity compared with COVID-19 or influenza disease among unvaccinated patients and more severe than COVID-19 or influenza disease among vaccinated patients for the most serious outcomes of IMV or death.

CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation

Monday, April 1, 2024
Junxiong Chen
CONCLUSIONS: Distinct from its canonical function in strengthening cell adhesion at cell surface, CD151 maintains endolysosome function by sustaining VCP/p97-mediated protein unfolding and turnover. By supporting protein quality control and protein degradation, CD151 prevents proteins from (1) buildup in endolysosomes and (2) discharge through exosomes, to limit vascular inflammation. Also, our study conceptualizes that balance between degradation and discharge of proteins in endothelial cells...

Homozygous missense variants in YKT6 result in loss of function and are associated with developmental delay, with or without severe infantile liver disease and risk for hepatocellular carcinoma

Sunday, March 24, 2024
Mengqi Ma
CONCLUSION: The YKT6 variants are partial loss-of-function alleles and the p.(Tyr185Cys) is more severe than p.(Tyr64Cys).