Carver College of Medicine Events
Live from Prairie Lights | Meghan O’Gieblyn in conversation with Dr. Alison Lynch — "Will and Attention"
Thursday, October 8, 2026 7:00pm to 8:00pm
Meghan O’Gieblyn in conv with Dr. Alison Lynch - Will and Attention
Meghan O’Gieblyn will read from her new memoir, Will and Attention, and will be joined in conversation with Dr. Alison Lynch. Described as a "luminous memoir of secret drinking, fragile recovery, and the deep pull of religion," Will and Attention is praised by bestselling author Jia Tolentino as "one of the best memoirs of the decade," while University of Iowa Nonfiction Writing Program professor and bestselling author Melissa Febos says: "An elegant and philosophical memoir about addiction whose stakes are no less than what comprises one's will to live, what it means to be good, and the worth of devotion. I savored equally O'Gieblyn's sentences and the turns of her thought—at once precise as the cut of a razor and as pleasurably discursive as Montaigne."
Hawk-IDDRC Seminar Series featuring Maja Bucan, PhD: "Sleep and activity patterns in autism”
Friday, October 9, 2026 12:00pm to 1:00pm
Please join us for our first Hawk-IDDRC Seminar of the academic year, featuring: Maja Bućan, PhD.
Professor, Departments of Genetics and Psychiatry; Co-director, Autism Spectrum Program Of Excellence, Perelman School of Medicine, University of Pennsylvania
Lurie Autism Institute, Children’s Hospital of Philadelphia and PennMedicine
Presenting: "Sleep and activity patterns in autism” Friday, October 9, 2026, Noon – 1pm CST in the Kelch Conference Room (CBRB 1289)
Lunch will be available for those who...
Anatomy of an Idea - Tom Rutkowski
Friday, October 9, 2026 12:00pm to 1:00pm
Recent Articles from the University of Iowa
Monocyte-derived pro-angiogenic ocular macrophages identified by spatial transcriptomics are essential for choroidal neovascularization
Thursday, October 8, 2026
The human retina and underlying choroid have multiple well-organized vascular layers. However, retinal and choroidal neovascularization can develop in diseases such as diabetic retinopathy or neovascular age-related macular degeneration, which can result in destructive vision loss. Ocular macrophages are implicated in the pathogenesis of such neovascular diseases. To identify a potential pro-angiogenic macrophage subtype, we integrated 13 single-cell RNA sequencing datasets from human and mouse...
Bronchiectasis prevalence, incidence, and exacerbation rates among insured adults in the U.S.: a descriptive analysis
Tuesday, October 6, 2026
CONCLUSIONS: Observed prevalence-incidence widening gap suggests case accumulation over time and survival among continuously enrolled beneficiaries. Exacerbation burden was concentrated among individuals with prior exacerbations, chronic airway infection, and respiratory comorbidity, while exacerbation rates decreased over time across payers and subgroups, in part reflecting changes in cohort composition.
Dicer-independent miR-451a is upregulated in periodontitis and potentiates inflammation by impairing macrophage polarization and SOCS activity
Tuesday, October 6, 2026
CONCLUSION: miR-451a is a pathogen-responsive, PD-associated miRNA that promotes pro-inflammatory macrophage polarization, impairs bacterialphagocytosis, and amplifies inflammation through suppression of SOCS-mediated immune regulation. These findings identify the miR-451a-SOCS3/SOCS5 axis as a potential mechanism linking bacterial challenge to dysregulated macrophage responses in PD.
Efficient host transmission of measles virus: disentangling misconceptions from established findings
Monday, October 5, 2026
SUMMARYMeasles virus (MeV) is considered the most contagious human virus. This review critically examines explanations for MeV's extraordinary transmissibility. Although substantial progress has been made in understanding MeV infection, pathogenesis, and host spread, the fundamental question of why MeV is markedly more transmissible than other structurally similar respiratory viruses within the same taxonomic families remains unresolved. Many commonly cited explanations are either incorrect,...
Denecimig (Mim8) prophylaxis over 52 weeks in adolescents and adults with hemophilia A: FRONTIER2 extension study
Friday, October 2, 2026
CONCLUSIONS: Denecimig maintained low ABRs over 52 weeks, was well tolerated, and improved patient-reported outcomes in adolescents and adults with HA with or without inhibitors.
Loss of CsrA in <em>Acinetobacter baumannii</em> leads to lethal dysregulation of alanine metabolism
Tuesday, September 29, 2026
Posttranscriptional regulation is a key mechanism by which bacteria coordinate gene expression in response to changing environments. In the human pathogen Acinetobacter baumannii, the importance of posttranscriptional gene expression control is exemplified by CsrA, a highly conserved posttranscriptional regulator that is essential for viability in multiple settings, ranging from growth in rich laboratory media to infection-relevant conditions like human serum. However, csrA is dispensable for...
IRE1alpha Is Associated with Host Lipid Biosynthesis During Human Coronavirus OC43 Infection
Saturday, September 26, 2026
Research into the replication of human coronaviruses has surged, but much remains unknown regarding the host factors that influence disease. These viruses often activate cellular endoplasmic reticulum (ER) stress responses, benefiting from incompletely understood downstream effects. In this study, we investigated the role of the host ER stress response component, inositol-requiring enzyme 1 α (IRE1α), in regulating lipid metabolism during human coronavirus OC43 (HCoV-OC43) infection. We found...
Impaired regulatory T-cell-mediated immune tolerance promotes neurodegeneration in glaucoma
Thursday, September 24, 2026
Neurodegenerative diseases are increasingly recognized to involve detrimental interactions between the immune and nervous systems, yet whether failure of peripheral immune tolerance actively drives neuronal loss frequently remains unclear. Here, using primary open-angle glaucoma as a model of chronic neurodegeneration, we demonstrate that dysregulated adaptive immunity is sufficient to promote retinal ganglion cell degeneration. Peripheral blood mononuclear cells from glaucoma patients, but not...
The Virtual Eye: An Integrative Multiscale Framework for Mechanistic Modelling of Ocular Physiology and Disease
Monday, September 21, 2026
The Virtual Eye initiative described here seeks to build a versatile and integrative in silico platform, 'The Virtual Eye' that can capture and simulate the biology, physiology and function of the human eye, from molecular interactions to organ-level behaviour, in both healthy and diseased states. This effort has the potential to substantially deepen our understanding of the visual process, clarify the mechanistic basis of ocular diseases across multiple spatial and temporal scales, and support...
A Zur-dependent regulatory RNA involved in maintaining zinc homeostasis in Staphylococcus aureus
Friday, September 18, 2026
Small regulatory RNAs (sRNAs) are key drivers of bacterial adaptation to environmental fluctuations, including iron and manganese restriction imposed by the host. This study explored the repertoire of sRNAs produced by the human pathogen Staphylococcus aureus in response to metal limitation. Two sRNAs were identified, S1077 and ZinS, that were regulated by zinc (Zn) availability. Further investigations revealed that, similar to the cnt operon from which it derives, S1077 synthesis is controlled...