Carver College of Medicine Events
Department of Microbiology and Immunology Seminar Series
Tuesday, December 2, 2025 3:00pm to 4:00pm
Seminar Series https://microbiology.medicine.uiowa.edu/about-us/seminars
Student Impact Grant Presentations
Tuesday, December 2, 2025 4:00pm
Hear from the eight 2025 Student Impact Grant recipients and learn how private support enhanced their Iowa experience. Student Impact Grants are made possible by generous gifts from alumni and friends who provide unrestricted support to the university.
About Student Impact Grants
The University of Iowa Office of the President and the Student Advancement Network have partnered to create Student Impact Grants, which provide funding for undergraduate and graduate student activities outside of the...
Hardin Open Workshops - EndNote Desktop (Zoom)
Wednesday, December 3, 2025 11:00am to 12:00pm
EndNote is a reference management tool that helps you to easily gather together your references in one place, organize them, and then insert them into papers and format them in a style of your choosing. This session will walk you through the basics of using EndNote to collect and format your citations. The class will be hands-on, and there will be time for questions at the end.
PLEASE NOTE
Enrollment in HOW is open to all University of Iowa affiliates and residents of the state of Iowa. Advance...
Internal Medicine Grand Rounds 12/4/2025
Thursday, December 4, 2025 12:00pm to 1:00pm
Annette Fitz Memorial Fellowship Lecture = presenter: Jordana Cohen, MD, MSCE, Penn Medicine
Neuroscience & Pharmacology Workshop - Bertha Martin, PhD & Budhaditya Basu, PhD
Thursday, December 4, 2025 12:30pm to 1:30pm
Molecular and Spatial Characterization of Caudal Raphe Cell Types
Bertha Martin, PhD
Postdoctoral Scholar
Dr. Jon Resch's Lab
Impact of tau pathology on learning-induced gene expression: A spatial transcriptomics approach
Budhaditya Basu, PhD
Postdoctoral Scholar
Dr. Snehajyoti Chatterjee's Lab
Recent Articles from the University of Iowa
Cannabinoids shift the basal ganglia microRNA m<sup>6</sup>A methylation profile towards an anti-inflammatory phenotype in SIV-infected rhesus macaques
Tuesday, November 25, 2025
Epitranscriptomic modifications [N6-methyladenosine (m⁶A)] regulate various diseases, including cancer and inflammation. Despite their functional relevance in neural development and differentiation, the role of m⁶A modifications in HIV neuropathogenesis is unknown. Using anti-N6-methyladenosine (m⁶A) antibody-immunoprecipitation and microarray profiling, we identified m⁶A modifications in miRNAs in basal ganglia (BG) of uninfected (VEH) and SIV-infected Rhesus macaques (RMs) on combination...
Mitochondrial targeting by measles virus nucleoprotein modulates viral spread in human airway epithelium
Thursday, November 20, 2025
Measles is the most infectious human respiratory virus: on average, one individual with measles infects 12-18 susceptible people in a population without immunity. However, how measles virus (MeV) establishes infection in the human respiratory epithelium is insufficiently understood. Since our analyses of MeV infections of well-differentiated primary human airway epithelial cells (HAE) revealed perturbations of mitochondrial gene expression, we tested mitochondrial function. MeV replication...
In vitro characterization of cellular responses elicited by endosomal TLR agonists encapsulated in Qβ virus-like particles
Tuesday, November 18, 2025
CONCLUSIONS: In summary, endosomal TLRa VLPs all have the ability to activate pDCs, however, combined TLR7/8 activation using TLR7/8a VLPs was significantly more effective than the other VLPs at activating T cells and was dependent on direct contact with pDCs. Therefore, TLR7/8a VLPs may potentially induce a robust anti-tumor immune response and warrant further investigation for cancer therapy.
Pro-inflammatory secreted virulence factors of <em>Staphylococcus capitis</em> causing a rare occurrence of severe native hip joint infection
Monday, November 17, 2025
CONCLUSION: Our data suggest that the inflammatory lesion in the patient's right hip was due to S. capitis subspecies capitis, and furthermore, it is likely that two secreted proteins (autolysin and an analog of immunodominant antigen B) contributed to the inflammation.
Fully automated IVUS image segmentation with efficient deep-learning-assisted annotation
Monday, November 17, 2025
Intravascular ultrasound (IVUS) image segmentation plays a critical role in the diagnosis, treatment planning, and monitoring of coronary artery disease. Although deep learning (DL) methods have achieved state-of-the-art (SOTA) results in various medical image segmentation tasks, effectively delivering clinically acceptable results remains challenging due to the limited availability of large annotated datasets. In this paper, we report an efficient deep learning framework for fully automated...
Long COVID trajectories in the prospectively followed RECOVER-Adult US cohort
Monday, November 17, 2025
Longitudinal trajectories of Long COVID remain ill-defined, yet are critically needed to advance clinical trials, patient care, and public health initiatives for millions of individuals with this condition. Long COVID trajectories were determined prospectively among 3,659 participants (69% female; 99.6% Omicron era) in the National Institutes of Health Researching COVID to Enhance Recovery (RECOVER) Adult Cohort. Finite mixture modeling was used to identify distinct longitudinal profiles based...
Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors
Thursday, November 13, 2025
Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, yet predicting patient response remains a major challenge. Carcinoma ecotypes, which capture the cancer-immune interactions, show promise as prognostic biomarkers but remain untested in real-world settings. We compile and analyze the ORIEN Avatar ICI cohort of 1610 patients with matched gene expression data from a broader dataset of 14,997 individuals. Using EcoTyper-based immunophenotyping, we define ecotypes and assess...
Alterations in Cardiovascular Parameters in 5xFAD Murine Model
Tuesday, November 11, 2025
Alzheimer's Disease (AD) is a global health issue, affecting over 6 million people in the United States, with that number expected to increase as the population ages. As a neurodegenerative disorder that affects memory and cognitive functions, it is well established that AD is associated with cardiovascular risk factors beyond only cerebral decline. In this study, we measured hemodynamic parameters related to cardiovascular and cerebrovascular function in 5xFAD mice with AD and their...
Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma
Wednesday, November 5, 2025
Mantle cell lymphoma (MCL) is a genetically and clinically heterogeneous B-cell malignancy. We studied two MCL cohorts with differing treatment patterns: one enriched for immunochemotherapy, the other for chemotherapy alone. TP53 alterations are consistently associated with poor prognosis, whereas ATM mutations correlate with improved outcomes following rituximab-based chemotherapy. Based on recurrent genetic events, six clusters are identified and refined into three prognostic groups: high-risk...
Atopic dermatitis, primary atopic disorders, and the cutaneous microbiome: current understanding of an expanding field
Monday, November 3, 2025
Atopic dermatitis is a common inflammatory skin disease with rapidly expanding worldwide prevalence. Increasingly, cases of severe and early-onset dermatitis have been identified and found to be due to underlying monogenic mutations, leading to immune dysregulation. These conditions, called primary atopic disorders, have become an area of extensive study over the last 30 years. Simultaneously, our understanding of the human microbiome has steadily grown, and there is clear evidence that...