Carver College of Medicine Events
TriNetX Basic Training
Thursday, June 26, 2025 9:00am to 10:00am
This training will provide an in-depth look at TriNetX and show you how to use the tool. We will go through building a study, searching for a specific population, and finally what information you can gather from the specific cohort. We will also discuss next steps on getting data extracted for research.
After this training you will have a thorough understanding of how to use TriNetX and what the process is to get data extracted for research studies.
Register by clicking the virtual event link...
Internal Medicine Grand Rounds 6/26/2025
Thursday, June 26, 2025 12:00pm to 1:00pm
"Toxicology Grand Rounds,"by Daniel McCabe, MD (Emergency Medicine)
Antimicrobial Stewardship Series: Antimicrobial Stewardship in Dental Practice: Principles and Practice
Friday, June 27, 2025 12:00pm to 1:00pm
Iowa Statewide Antimicrobial Stewardship Initiative – a partnership between Iowa Health and Human Services and UI College of Pharmacy in conjunction with the UI Carver College of Medicine Department of Continuing Education present the following seminar by Karen Baker, MS:"Antimicrobial Stewardship Series: Antimicrobial Stewardship in Dental Practice: Principles and Practice"Continuing education available.
Molecular Medicine Interdisciplinary Program Thesis Defense Seminar: Nathan Witmer
Monday, June 30, 2025 10:00am
Nathan Witmer is a PhD candidate in the Biomedical Science (Molecular Medicine) Interdisciplinary Graduate Program. His research has been conducted in Ryan Boudreau's laboratory.If you are not able to attend in person, please consider showing your support by attending via Zoom. https://uiowa.zoom.us/j/95883392288
Topics in Human Genetics
Monday, June 30, 2025 12:00pm to 1:00pm
The course is open to individuals wishing to learn more about current topics in Human Genetics who meet the following criteria; individuals must have completed a course in genetics and are currently in a genetics lab, or have past genetics research experience. Genetics educators are also welcome to attend the course.The objective of the course is to provide persons familiar with genetics a broad overview of gene identification, molecular genetics, complex disease, next generation sequencing...
Recent Articles from the University of Iowa
Skin levels of toxic shock syndrome toxin-1 predict the severity of atopic dermatitis
Tuesday, June 17, 2025
No abstract
Maternal α-cypermethrin and permethrin exert differential effects on fetal growth, placental morphology, and fetal neurodevelopment in mice
Sunday, June 15, 2025
Pyrethroid insecticides represent a broad class of chemicals used widely in agriculture and household applications. Human studies show mixed effects of maternal pyrethroid exposure on fetal growth and neurodevelopment. Assessment of shared pyrethroid metabolites as a biomarker for exposure obscures effects of specific chemicals within this broader class. To better characterize pyrethroid effects on fetal development, we investigated maternal exposure to permethrin, a type I pyrethroid, and...
Do active learning techniques promote higher academic performance in an online graduate anatomy course?
Saturday, June 14, 2025
Human anatomy is a foundational course in graduate health professional programs. Given the increased enrollment in anatomy courses, along with the development of new technologies, institutions are increasingly compelled to provide alternative course formats, including online learning. Similarly, higher education is increasingly transitioning from traditional lecture-based learning to methods that allow students to actively participate in their own learning process (i.e., active learning). Active...
Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages
Friday, June 13, 2025
Stem cells are known to provide signals that contribute to the maintenance and function of neighboring cells. We demonstrate that Notch signaling arising from airway basal stem cells is necessary for the function of a unique population of intraepithelial airway macrophages (IAMs) in the murine trachea. Without this stem cell signaling, IAMs lose MHC II expression, which in turn prevents antigen-induced allergic inflammation. Distal murine airways do not harbor basal stem cells, and, in this...
Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes
Friday, June 13, 2025
Recent studies have highlighted the presence of memory T cells in human brains, some of which are specific for peripheral infections. To address their potential origins, we used two models of polymicrobial exposure to 'normalize' the immune systems of specific pathogen-free mice and queried the impact on brain T cell biology. Here, we show that cohousing and sequential infection induce marked enhancement of memory T cells in the brain tissue of mice. These resident and circulating memory T cells...
Inhibition of Influenza Entry by Organosilicon Compounds
Tuesday, June 10, 2025
Hemagglutinin (HA) plays a critical role in the entry of influenza and thus HA is a target for the development of entry inhibitors as antivirals. One of the first small molecule inhibitors of influenza entry to be described was tert-butylhydroquinone (TBHQ), a commonly used antioxidant. This compound was shown to inhibit influenza containing Group 2 HA, such as H3 and H7 HA circulating in humans and avians. One limitation of TBHQ is the propensity to oxidize in solution, resulting in a less...
Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy
Monday, June 2, 2025
INTRODUCTION: Dysregulation of the alternative pathway of complement underlies the pathogenesis of C3 glomerulopathy (C3G). Because Factor H (FH) prevents excessive alternative pathway activity while Factor H-related protein 1 (FHR-1) is believed to enhance this response, we investigated the balance between FH and FHR-1 in C3G.
Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs
Friday, May 30, 2025
Transfer RNAs (tRNAs) are fundamental for both cellular and viral gene expression during viral infection. In addition, mounting evidence supports the biological function for tRNA cleavage products, including the control of gene expression during conditions of stress and infection. We previously reported that infection with the model murine gammaherpesvirus 68, MHV68, leads to enhanced tRNA transcription. However, whether this has any influence on tRNA transcript processing, viral replication, or...
Naturally transmitted mouse viruses highlight the heterogeneity of virus transmission dynamics in the dirty mouse model
Wednesday, May 28, 2025
Specific-pathogen-free (SPF) mice are widely used in biomedical research to model human infections. However, these animals do not always accurately recapitulate human immune responses. This is due, in part, to their lack of infection history. A growing number of studies show that the host microbiome influences the development, progression, and responses of many diseases. To date, the majority of research on the microbiome has focused on the bacterial populations and less on the eukaryotic virome...
WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity
Wednesday, May 28, 2025
Tissue-resident macrophages (TRM) are critical for mammalian organismal development and homeostasis. Here we report that with-no-lysine 1 (WNK1) controls myeloid progenitor fate, with Csf1r^(iCre)-mediated Wnk1 deletion in mice (WNK1-deficient mice) resulting in loss of TRMs and causing perinatal mortality. Mechanistically, absence of WNK1 or inhibition of WNK kinase activity disrupts macrophage colony-stimulating factor (M-CSF)-stimulated macropinocytosis, thereby blocking mouse and human...