Carver College of Medicine Events
Microbiology Graduate Program - PhD Thesis Seminar - Riley McFarlane
Monday, April 13, 2026 10:00am to 11:00am
Microbiology PhD Thesis Seminar - PhD Candidate - Riley McFarlane
Seminar Title: Stress management: a balancing act performed by Staphylococcus aureus
Women In Micro & Immuno Coffee Hour
Monday, April 13, 2026 11:00am to 12:00pm
Join us for the Women in Micro & Immuno Coffee Hour. It is the monthly coffee hour on the second Monday of the month from 11 a.m. to noon in 1289 CBRB. Enjoy coffee, pastries and contribute to the discussion!
This is open to ALL — students, staff, postdocs, and faculty interested in promoting women in science.
Speakers change monthly. Contact: jessica-tucker@uiowa.edu for details.
Clinical Science Rounds: Mark Niciu
Monday, April 13, 2026 12:30pm to 1:20pm
Dr. Niciu is an Assistant Professor of Psychiatry at the University of Iowa Carver College of Medicine. The Niciu Lab is broadly interested in the pathophysiology and experimental therapeutics of major mood disorders, particularly glutamate and subanesthetic-dose ketamine in treatment-resistant major depression. His work is also aimed at furthering the identification, replication, and dissemination of antidepressant response biomarkers.
REDCap Advanced Training
Tuesday, April 14, 2026 10:00am to 11:00am
This is the fourth step in the REDCap training series. In this training we will cover advanced features such as:
Importing data from a CSV file
Ways to customize your data entry experience with form display logic
Making your forms more dynamic and personalized with context aware smart variables
Sending automated, conditional email alerts
Ensuring data is high quality by executing data quality rules, creating data 'missingness' codes, and opening data queries
Register by clicking the virtual event link...
Neuroscience and Pharmacology Seminar - Scott Mittelstadt, PhD
Tuesday, April 14, 2026 10:30am to 11:30am
Preclinical Safety in Drug Development
Scott Mittelstadt, PhD
Vice President of Preclinical Safety
AbbVie Inc.
Recent Articles from the University of Iowa
A Pre-Clinical Model of Synovitis Using Ex vivo Human Synovial Tissue with Preserved Function and Architecture
Monday, April 6, 2026
Arthritis is an inflammatory state within joints resulting in cartilage damage, pain, and loss of mobility. Recent advances in arthritis research specifically demonstrate that the joint capsule (e.g., synovium) is an important source of this inflammation, but there are no human models that replicate essential synovial architecture. To address this, the Joint Space Analysis System, or JSAS, was created. Anterior synovium was obtained intra-operatively from patients undergoing Total Knee...
Global burden of cancer in children and adolescents aged 0-19 years, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023
Sunday, April 5, 2026
BACKGROUND: Information on childhood cancer burden is crucial for effective cancer policy planning. Unfortunately, observed paediatric cancer data are not available in every country, and previous global burden estimates have not discretely reported several common cancers of childhood. We aimed to inform efforts to address childhood cancer burden globally by analysing results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023, which now include nine additional cancer...
The ULK1-NCOA3 axis restrains de novo lipogenesis and prevents diet-induced steatohepatitis and fibrosis in mice
Thursday, April 2, 2026
Metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) are leading causes of cirrhosis and hepatocellular carcinoma. Defects in autophagy contribute to the development of MASLD, however, the role of the Unc-51-like autophagy-activating kinase 1 (ULK1) in the pathophysiology of MASLD remains unclear. Herein, we show that ULK1, a serine/threonine kinase and core autophagy protein, is significantly repressed in human MASH livers, and that hepatocyte-specific...
Pharmacological METTL3 inhibition attenuates HIV-1 latency reversal in CD4<sup>+</sup> T cells
Friday, March 27, 2026
N ⁶-methyladenosine (m⁶A) is a major epitranscriptomic modification that regulates RNA metabolism and affects the replication and latency reversal of human immunodeficiency virus type 1 (HIV-1) in cells. Methyltransferase-like 3 (METTL3) is the principal catalytic enzyme responsible for m⁶A deposition, and its pharmacological inhibition has emerged as a potential therapeutic strategy for cancer and viral infections. However, the relative potency of METTL3 inhibitors in reducing m⁶A levels and...
Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats
Saturday, March 21, 2026
Transcription factors play a key role in regulating gene expression. We conduct an integrated analysis of chromatin accessibility, DNA methylation, mRNA expression, protein abundance and phosphorylation across eight tissues in fifty rats of equally represented sexes following endurance exercise training to identify coordinated epigenomic and transcriptional changes and determine key transcription factors involved. We uncover tissue-specific endurance exercise training associated changes and...
Elevated m<sup>6</sup>A RNA modifications associate with immune dysregulation and cancer in people with HIV-1
Saturday, March 21, 2026
No abstract
SAMHD1 depletion restricts SARS-CoV-2 infection by suppressing HNF1-dependent ACE2 expression in lung epithelial cells
Thursday, March 19, 2026
Sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) restricts a broad spectrum of viruses through multifaceted mechanisms. It also limits spontaneous- and virus-induced innate immune responses by suppressing proinflammatory cytokine and type-I interferon (IFN-I) production. Some viruses escape SAMHD1 restriction and utilize SAMHD1-mediated innate immune suppression to establish effective infection through IFN antagonism. Our previous studies showed that SAMHD1 is a...
Loss of Infectivity of Influenza Virus and SARS-CoV‑2 during Aerosol Sampling
Monday, March 16, 2026
Our understanding of transmission of influenza virus and other respiratory viruses is limited by the difficulty of detecting infectious viruses in aerosol particles. Most aerosol sampling methods are believed to contribute to virus inactivation, but the magnitude of this sampling artifact is unknown. To investigate this question, we aerosolized influenza A virus (IAV) and SARS-CoV-2 suspended in human saliva into a small chamber (3.7 L). Aerosols settled for 10 min onto either cells or a thin...
The interplay between temperature and growth phase shapes the transcriptional landscape of <em>Pseudomonas aeruginosa</em>
Wednesday, March 11, 2026
Pseudomonas aeruginosa is a highly versatile bacterium capable of surviving and often thriving in stressful environmental conditions. Here, we report the effect of two environmental conditions, temperature and growth phase, on the P. aeruginosa PAO1 transcriptome. As P. aeruginosa is well-known for its growth phase dependent phenotypes and gene regulation, our goal was to determine how temperature altered global gene expression at exponential versus stationary phase and to characterize how...
Case Report: Novel <em>MAGT1</em> pathogenic variant with significant atopy, hypogammaglobulinemia and viral skin infections
Wednesday, March 4, 2026
CONCLUSION: This case illustrates how a synergistic multi-disciplinary team approach established a diagnosis of XMEN disease in a patient with an atypical clinical presentation. This case also highlights a growing trend where established diagnostic tools such as flow-cytometry and genomics can be complemented with newer, sophisticated analytical approaches such as AlphaFold to further elucidate the functionally crippling effects of novel variants described in the setting of IEI.