Carver College of Medicine Events
Biomedical & Health Informatics Community Meeting
Thursday, January 8, 2026 12:00pm to 1:00pm
We have established a community of CCOM Informaticists who are applying these skills in their work at UIHC. You are invited to join us during our monthly seminar presentations.
Women In Micro & Immuno Coffee Hour
Monday, January 12, 2026 11:00am to 12:00pm
Join us for the Women in Micro & Immuno Coffee Hour. It is the monthly coffee hour on the second Monday of the month from 11 a.m. to noon in 1289 CBRB. Enjoy coffee, pastries and contribute to the discussion!
This is open to ALL — students, staff, postdocs, and faculty interested in promoting women in science.
Speakers change monthly. Contact: jessica-tucker@uiowa.edu for details.
Improving Health Outcomes Through Preventing Childhood Obesity Conference
Tuesday, January 13, 2026 8:30am to 4:30pm
Join physicians, nurses, public health educators, researchers, teachers, social workers and dietitians in a conversation about the prevention of, and the implications of, childhood obesity!
Join physicians, nurses, public health educators, researchers, teachers, social workers and dietitians in a conversation about the prevention of, and the implications of, childhood obesity!
Join physicians, nurses, public health educators, researchers, teachers, social workers and dietitians in a conversation about the prevention of, and the implications of, childhood obesity!
Skills for Educators Workshop: Clinical Teaching
Friday, January 16, 2026 8:30am to 11:30am
Develop effective and efficient approaches to teaching in the context of patient care.
BMB Research Workshop
Tuesday, January 20, 2026 12:30pm to 1:20pm
The Department of Biochemistry and Molecular Biology holds research workshops featuring internal speakers on Tuesdays, 12:30-1:20pm. For Spring 2026, these will occur in 2117 MERF. Presentation titles are not publicly available due to the use of unpublished research. Individuals interested in attending workshops or being added to the email list should contact the office at biochem@uiowa.edu.
Jan. 20: open
Jan. 27: open
Feb. 3: open
Feb. 10: open
Feb. 17: Tyler Woodward, PhD Candidate, 4th Year...
Recent Articles from the University of Iowa
Hfq orchestrates a robust RNA-RNA interaction network in <em>Acinetobacter baumannii</em>
Wednesday, December 17, 2025
Across bacteria, RNA binding proteins, such as Hfq, often play a key role in facilitating post-transcriptional regulation by chaperoning interactions between small regulatory RNAs (sRNAs) and their mRNA targets. Acinetobacter baumannii, a problematic gram-negative bacterial pathogen, produces over a hundred sRNAs, of which only a few have experimentally validated mRNA targets. While previous studies have identified hfq as a candidate essential gene in the model multidrug-resistant A. baumannii...
Feasibility and Safety of Aerosolized Influenza Virus Challenge in Humans Using Two Modern Delivery Systems
Tuesday, December 16, 2025
CONCLUSIONS: In this small pilot, aerosolized challenge using modern delivery systems was feasible under controlled conditions; no safety concerns were identified, and MMID was induced in a subset of participants. These data establish a methodological framework for future studies evaluating pathogenesis and mucosal immune responses to a variety of respiratory pathogens.
Expression and Prognostic Significance of PD-1/PD-Ls in Breast Cancer Draining Lymph Nodes
Monday, December 15, 2025
CONCLUSION: Elevated expression of PD-1 and its ligands in BC-draining lymph nodes is associated with adverse clinical features, suggesting their role in immune evasion. These findings along with higher frequency of PD-1+ lymphocyte in triple-negative patients may inform subtype-specific therapeutic strategies and predict responsiveness to PD-1/PD-Ls blockade therapies. Future studies should include functional analyses with broader immunophenotyping to further elucidate these mechanisms.
Interferon-stimulated gene GALNT2 restricts respiratory virus infections
Friday, December 12, 2025
The innate immune response involves interferons (IFNs), antiviral cytokines that upregulate numerous IFN-stimulated genes, many of which have uncharacterized functions and mechanisms. Here we performed transcriptomic profiling of lung tissues from wild-type and IFNAR^(-/-) mice infected with SARS-CoV-2 and single-cell RNA sequencing of bronchoalveolar lavage fluid and peripheral blood mononuclear cells from patients with COVID-19. We identified O-GalNAc transferase 2 (GALNT2), an...
<em><em>Vibrio cholerae</em></em> biofilm matrix assembly and growth are shaped by a glutamate-specific TAXI/TRAP protein
Tuesday, December 9, 2025
Biofilms are critical for the environmental persistence, survival, and infectivity of Vibrio cholerae, the causative agent of cholera. Here, we find that GluP, a glutamate-specific TRAP-TAXI protein, is an uncharacterized matrix component that plays a critical role in biofilm architecture. Loss of GluP reduces biofilm corrugation, expands colony size, and disperses cells from microcolonies, arguing that this factor maintains biofilm structure and organization. While GluP does not affect the...
INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model
Sunday, December 7, 2025
Glioblastoma is a lethal brain cancer marked by functional plasticity driven by tumor cell-intrinsic mutations and their interplay with developmental programs. To investigate how canonical glioblastoma mutations promote functional plasticity, we have developed an isogenic human neural stem cell (NSC) model of glioblastoma by sequential addition of TERT promoter, TP53, and PDGFRA point mutations. TP53 loss-of-function increases TERT expression during serial mutagenesis, but only triple mutant...
Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice
Monday, December 1, 2025
INTRODUCTION: Administering high levels of oxygen is a life-sustaining measure in critically ill lung subjects. However, prolonged hyperoxia exposure increases reactive oxygen species (ROS) that exacerbate oxidative stress, mitochondrial dysfunction, respiratory failure, and cell death. Mitochondria play a critical role in hyperoxia-induced acute lung injury (HALI). The specific role of the Polycomb Repressive Complex 1 protein BMI1 (B cell-specific Moloney murine leukemia virus integration site...
Extracellular condensates (ECs) are endogenous modulators of HIV transcription and latency reactivation
Saturday, November 29, 2025
The persistence of HIV latent reservoir is the major challenge to HIV cure because latent viruses serve as sources for viral rebound upon ART cessation. Mechanisms regulating viral persistence are not well understood; thus, there is a compelling need for research focusing on addressing the knowledge gap related to HIV persistence. The present study focuses on the effect of extracellular condensates (ECs) on latent HIV/SIV reactivation in the brain in the context of HIV infection using the...
Reactivating necroptosis in colorectal cancer potentiates chemotherapy and antitumor immune responses
Friday, November 28, 2025
Necroptosis, a form of immunogenic cell death (ICD), is frequently impaired in cancer due to the silencing of key regulators, such as RIP3. Despite its potential immunogenic benefits, restoring necroptosis in cancer therapy has been largely underexplored, primarily due to the lack of effective strategies or agents that specifically engage necroptosis without activating apoptosis. In this study, we investigated strategies to restore necroptosis for chemosensitization in RIP3-silenced colorectal...
Non-Vesicular Extracellular Particle (NVEP) Proteomes from Diverse Biological Sources Reveal Specific Marker Composition with Varying Enrichment Levels
Thursday, November 27, 2025
Extracellular particles (EPs), an umbrella term encompassing membrane-enclosed extracellular vesicles (EVs) and non-vesicular extracellular particles ([NVEPs], previously described as extracellular condensates [ECs]) contain a complex cargo of biomolecules, including DNA, RNA, proteins, and lipids, reflecting the physiological state of their cell of origin. Identifying proteins associated with EPs that regulate host responses to physiological and pathophysiological processes is of critical...