Carver College of Medicine Events
Neuroscience Interdisciplinary Program Thesis Defense Seminar: Samantha Pierson
Wednesday, November 6, 2024 9:00am
Samantha Pierson is a current student of the Neuroscience Graduate Program and is in Dr. Catherine Marcinkiewcz's laboratory. She is excited to announce her thesis seminar.
Pain Research Program Presentation - Jamie Morton, PhD, RN & Giovanni Berardi, DPT, PhD
Wednesday, November 6, 2024 9:00am to 10:00am
"Exploring Pain, Trauma, Substance Use Disorder, and Family Dysfunction in Childbearing-Aged Females"
Presented by Jamie Morton, PhD, RN
Postdoctoral Research Scholar in Dr. Barbara St. Marie's lab
"Relation of immune cell phenotype to exercise-induced pain and fatigue in ME/CFS and PASC"
Presented by Giovanni Berardi, DPT, PhD
Postdoctoral Scholar in Dr. Kathleen Sluka's lab
ACB Seminar Series - Narendra Thapa
Wednesday, November 6, 2024 9:30am to 10:30am
Dr. Narendra Thapa, a Senior Scientist from the University of Wisconsin-Madison will present a seminar titled "Phosphoinositide Lipid Signaling in Health and Disease."
First-Generation Graduate Student Panel
Wednesday, November 6, 2024 11:00am to 12:00pm
Join us for First-Generation College Celebration Week at the University of Iowa with a First-Generation Graduate Student Panel, hosted by the Office of Graduate Student Success and Belonging. This event will showcase first-generation graduate students as they share their personal stories, including the challenges they've faced and the successes they've achieved throughout their academic journey.
Hardin Open Workshops - PubMed (Zoom)
Wednesday, November 6, 2024 12:00pm to 1:00pm
This hands-on session will help you improve your searching through best practices for basic and advanced searching and show you features for saving or exporting citations. The session will also help you understand medical subject headings (MeSH) and how they improve your search as well as the benefits of a MyNCBI account.
PLEASE NOTE:
Advance registration is required for Zoom classes. Registrants will be emailed the Zoom link 30 minutes before the class time.
Recent Articles from the University of Iowa
Development of Worksheets for Immunomodulator Shared Decision-Making to Facilitate Patient-Clinician Communication: A Quality Improvement Project Employing Design Thinking Principles
Wednesday, October 30, 2024
CONCLUSION: The WISDM template contains 7 elements that support SDM. Forty-five WISDMs were created for 23 immunomodulators. Further investigation will focus on how WISDMs exactly impact SDM.
Muscle inflammation is regulated by NF-κB from multiple cells to control distinct states of wasting in cancer cachexia
Wednesday, October 30, 2024
Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with local tissue inflammation. We queried the regulation of this inflammation and its causality to cachexia by exploring skeletal muscle, whose atrophy strongly associates with poor outcomes. Using multiple mouse models and patient samples, we show that cachectic muscle is marked by enhanced innate immunity. Nuclear factor κB (NF-κB) activity in...
Inflammation impacts androgen receptor signaling in basal prostate stem cells through interleukin 1 receptor antagonist
Friday, October 25, 2024
Chronic prostate inflammation in patients with benign prostate hyperplasia (BPH) correlates with the severity of symptoms. How inflammation contributes to prostate enlargement and/or BPH symptoms and the underlying mechanisms remain unclear. In this study, we utilize a unique transgenic mouse model that mimics chronic non-bacterial prostatitis in men and investigate the impact of inflammation on androgen receptor (AR) in basal prostate stem cells (bPSC) and their differentiation in vivo. We find...
Microbiome-based correction for random errors in nutrient profiles derived from self-reported dietary assessments
Tuesday, October 22, 2024
Since dietary intake is challenging to directly measure in large-scale cohort studies, we often rely on self-reported instruments (e.g., food frequency questionnaires, 24-hour recalls, and diet records) developed in nutritional epidemiology. Those self-reported instruments are prone to measurement errors, which can lead to inaccuracies in the calculation of nutrient profiles. Currently, few computational methods exist to address this problem. In the present study, we introduce a deep-learning...
Dynamic changes in macrophage polarization during the resolution phase of periodontal disease
Tuesday, October 22, 2024
CONCLUSION: Resolution of periodontal inflammation is associated with M1 to M2 Mφ polarization after nonsurgical periodontal therapy. Assessment of Mφ markers can provide relevant clinical information on the successful response of periodontal therapy and may be used to target nonresponders.
A comprehensive review of sensors of radiation-induced damage, radiation-induced proximal events, and cell death
Saturday, October 19, 2024
Radiation, a universal component of Earth's environment, is categorized into non-ionizing and ionizing forms. While non-ionizing radiation is relatively harmless, ionizing radiation possesses sufficient energy to ionize atoms and disrupt DNA, leading to cell damage, mutation, cancer, and cell death. The extensive use of radionuclides and ionizing radiation in nuclear technology and medical applications has sparked global concern for their capacity to cause acute and chronic illnesses. Ionizing...
Tissue resident memory T cells contribute to protectionagainst heterologousSARS-CoV-2 challenge
Tuesday, October 15, 2024
Widespread vaccination and natural infection have resulted in greatly decreased rates of severe disease, hospitalization and death after subsequent infection or reinfection with SARS-CoV-2. New vaccine formulations are based on circulating strains of virus, which have tended to evolve to more readily transmit human to human and to evade the neutralizing antibody response. An assumption of this approach is that ancestral strains of virus will not recur. Recurrence of these strains could be a...
Interactions of Polychlorinated Biphenyls and Their Metabolites with the Brain and Liver Transcriptome of Female Mice
Friday, October 11, 2024
Exposure to polychlorinated biphenyls (PCBs) is linked to neurotoxic effects. This study aims to close knowledge gaps regarding the specific modes of action of PCBs in female C57BL/6J mice (>6 weeks) orally exposed for 7 weeks to a human-relevant PCB mixture (MARBLES mix) at 0, 0.1, 1, and 6 mg/kg body weight/day. PCB and hydroxylated PCB (OH-PCBs) levels were quantified in the brain, liver, and serum; RNA sequencing was performed in the striatum, prefrontal cortex, and liver, and metabolomic...
Effects of 28-day nose-only inhalation of PCB52 (2,2',5,5'-Tetrachlorobiphenyl) on the brain transcriptome
Sunday, October 6, 2024
A semi-volatile polychlorinated biphenyl (PCB) congener, PCB52, is present in the indoor air of schools; however, the effects of inhaled PCB52 on the brain have not been investigated. This study exposed male Sprague-Dawley rats at 39 days of age and female rats at 42 days of age to PCB52 for 4 hours per day over 28 consecutive days through nose-only inhalation. Neurobehavioral tests were conducted during the last 5 days of exposure. The total estimated PCB52 exposures after 28 days were 1080±20...
Forecasting the effects of smoking prevalence scenarios on years of life lost and life expectancy from 2022 to 2050: a systematic analysis for the Global Burden of Disease Study 2021
Friday, October 4, 2024
BACKGROUND: Smoking is the leading behavioural risk factor for mortality globally, accounting for more than 175 million deaths and nearly 4·30 billion years of life lost (YLLs) from 1990 to 2021. The pace of decline in smoking prevalence has slowed in recent years for many countries, and although strategies have recently been proposed to achieve tobacco-free generations, none have been implemented to date. Assessing what could happen if current trends in smoking prevalence persist, and what...