Carver College of Medicine Events
Improving Health Outcomes Through Preventing Childhood Obesity Conference
Tuesday, January 13, 2026 8:30am to 4:30pm
Join physicians, nurses, public health educators, researchers, teachers, social workers and dietitians in a conversation about the prevention of, and the implications of, childhood obesity!
Join physicians, nurses, public health educators, researchers, teachers, social workers and dietitians in a conversation about the prevention of, and the implications of, childhood obesity!
Join physicians, nurses, public health educators, researchers, teachers, social workers and dietitians in a conversation about the prevention of, and the implications of, childhood obesity!
Hardin Open Workshops - EndNote Basic - Online Version (Zoom)
Tuesday, January 13, 2026 11:00am to 12:00pm
Hardin Open Workshops: EndNote Basic
ACB Seminar Series - Juan Rodriguez and Sahebgowda Patil
Wednesday, January 14, 2026 9:30am to 10:30am
Juan Rodriguez, a Cell and Developmental Biology Student in the Yang Lab, will present a seminar titled “Regulation of Ide-mediated Hepatic Insulin Clearance by Nitrosative Stress."
Sahebgowda Patil, a Cell and Developmental Biology Student in the Yang Lab, will present a seminar titled “Role of the Lysosome Enzyme GILT in Bone Marrow Adipocyte Function under the Context of Obesity."
Skills for Educators Workshop: Clinical Teaching
Friday, January 16, 2026 8:30am to 11:30am
Develop effective and efficient approaches to teaching in the context of patient care.
BMB Research Workshop
Tuesday, January 20, 2026 12:30pm to 1:20pm
The Department of Biochemistry and Molecular Biology holds research workshops featuring internal speakers on Tuesdays, 12:30-1:20pm. For Spring 2026, these will occur in 2117 MERF. Presentation titles are not publicly available due to the use of unpublished research. Individuals interested in attending workshops or being added to the email list should contact the office at biochem@uiowa.edu.
Jan. 20: open
Jan. 27: open
Feb. 3: open
Feb. 10: open
Feb. 17: Tyler Woodward, PhD Candidate, 4th Year...
Recent Articles from the University of Iowa
Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection
Wednesday, January 7, 2026
Post-acute sequelae of COVID-19 (PASC) encompasses persistent neurological disease, including olfactory and cognitive dysfunction. The basis for this dysfunction is poorly understood. Here, we report neurological dysfunction for at least 120 d postinfection in mice infected with a virulent nonneurotropic mouse-adapted SARS-CoV-2. Long after recovery from nasal infection, we observed diminished tyrosine hydroxylase expression in olfactory bulb glomeruli and in substantia nigra. Similar changes...
Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming
Saturday, January 3, 2026
Pulmonary group 2 innate lymphoid cells (ILC2s) are key drivers of Type 2 inflammation in diseases like asthma, yet the molecular mechanisms regulating their function are incompletely understood. Using the genetically diverse Collaborative Cross (CC) mouse panel, we mapped a quantitative trait locus (QTL) that governs ILC2 prevalence in the lung after aeroallergen exposure. This QTL induces a large population of ILC2s in the lung that are resistant to activation and have diminished Type 2...
Interferons Inhibit Ebola Virus Infection of Human Keratinocytes
Wednesday, December 31, 2025
Orthoebolavirus zairense is the species name for Zaire Ebola virus (EBOV) within Filoviridae. This group of viruses can cause severe disease in humans, characterized by hemorrhagic shock, coagulation abnormalities, and severe inflammation. While tissue macrophages are critical targets early during EBOV infection, other cell types support viral replication as disease progresses. At late stages of infection, infectious EBOV is found on the surface of the skin, which may be a critical source of...
Human macrophages release exosomes containing anti-inflammatory microRNAs after phagocytosis of Leishmania infantum
Friday, December 26, 2025
INTRODUCTION: The protozoan Leishmania infantum causes visceral leishmaniasis, a disease associated with suppressed systemic innate and adaptive immune responses. Mechanisms underlying the generalized immune suppression are incompletely understood. Exosomes are a subset of microvesicles released from eukaryotic cells, which contain proteins, lipids, and nucleic acids, including microRNAs (miRNAs). These small regulatory RNAs can simultaneously modify the expression of many genes and pathways. We...
Coinfection Ecology and Pathogen Emergence in a <em>Borrelia</em>-Endemic Landscape: Five Years of <em>Borrelia burgdorferi, Anaplasma phagocytophilum</em>, and <em>Babesia microti</em> Surveillance in Maryland
Thursday, December 18, 2025
The emergence of tick-borne pathogens depends on ecological opportunity and barriers to persistence within vectors and hosts. Borrelia burgdorferi is firmly entrenched in the mid-Atlantic, whereas Babesia microti and Anaplasma phagocytophilum remain patchily distributed. Five years of integrated surveillance (2020-2024) at three Maryland sites allowed us to track B. microti and A. phagocytophilum establishment by screening questing Ixodes scapularis nymphs, Peromyscus-fed nymphs, and Peromyscus...
Hfq orchestrates a robust RNA-RNA interaction network in <em>Acinetobacter baumannii</em>
Wednesday, December 17, 2025
Across bacteria, RNA binding proteins, such as Hfq, often play a key role in facilitating post-transcriptional regulation by chaperoning interactions between small regulatory RNAs (sRNAs) and their mRNA targets. Acinetobacter baumannii, a problematic gram-negative bacterial pathogen, produces over a hundred sRNAs, of which only a few have experimentally validated mRNA targets. While previous studies have identified hfq as a candidate essential gene in the model multidrug-resistant A. baumannii...
Feasibility and Safety of Aerosolized Influenza Virus Challenge in Humans Using Two Modern Delivery Systems
Tuesday, December 16, 2025
CONCLUSIONS: In this small pilot, aerosolized challenge using modern delivery systems was feasible under controlled conditions; no safety concerns were identified, and MMID was induced in a subset of participants. These data establish a methodological framework for future studies evaluating pathogenesis and mucosal immune responses to a variety of respiratory pathogens.
Expression and Prognostic Significance of PD-1/PD-Ls in Breast Cancer Draining Lymph Nodes
Monday, December 15, 2025
CONCLUSION: Elevated expression of PD-1 and its ligands in BC-draining lymph nodes is associated with adverse clinical features, suggesting their role in immune evasion. These findings along with higher frequency of PD-1+ lymphocyte in triple-negative patients may inform subtype-specific therapeutic strategies and predict responsiveness to PD-1/PD-Ls blockade therapies. Future studies should include functional analyses with broader immunophenotyping to further elucidate these mechanisms.
Interferon-stimulated gene GALNT2 restricts respiratory virus infections
Friday, December 12, 2025
The innate immune response involves interferons (IFNs), antiviral cytokines that upregulate numerous IFN-stimulated genes, many of which have uncharacterized functions and mechanisms. Here we performed transcriptomic profiling of lung tissues from wild-type and IFNAR^(-/-) mice infected with SARS-CoV-2 and single-cell RNA sequencing of bronchoalveolar lavage fluid and peripheral blood mononuclear cells from patients with COVID-19. We identified O-GalNAc transferase 2 (GALNT2), an...
<em><em>Vibrio cholerae</em></em> biofilm matrix assembly and growth are shaped by a glutamate-specific TAXI/TRAP protein
Tuesday, December 9, 2025
Biofilms are critical for the environmental persistence, survival, and infectivity of Vibrio cholerae, the causative agent of cholera. Here, we find that GluP, a glutamate-specific TRAP-TAXI protein, is an uncharacterized matrix component that plays a critical role in biofilm architecture. Loss of GluP reduces biofilm corrugation, expands colony size, and disperses cells from microcolonies, arguing that this factor maintains biofilm structure and organization. While GluP does not affect the...