Carver College of Medicine Events
Women In Micro & Immuno Coffee Hour
Monday, January 13, 11:00am to Monday, December 8, 2025 12:00pm
Join us for the Women in Micro & Immuno Coffee Hour. It is the monthly coffee hour on the second Monday of the month from 11 a.m. to noon in 1289 CBRB. Enjoy coffee, pastries and contribute to the discussion!
This is open to ALL — students, staff, postdocs, and faculty interested in promoting women in science.
Speakers change monthly. Contact: jessica-tucker@uiowa.edu for details.
Women In Micro & Immuno Coffee Hour
Monday, March 10, 2025 11:00am to Monday, February 2, 2026 11:00am
Join us for the Women in Micro & Immuno Coffee Hour. It is the monthly coffee hour on the second Monday of the month from 11 a.m. to noon in 1289 CBRB. Enjoy coffee, pastries and contribute to the discussion!
This is open to ALL — students, staff, postdocs, and faculty interested in promoting women in science.
Speakers change monthly. Contact: jessica-tucker@uiowa.edu for details.
ACB Seminar Series - Bethany Moore
Wednesday, March 12, 2025 9:30am to 10:30am
Dr. Bethany Moore, Professor and Chair of the Department of Microbiology and Immunology from the University of Michigan will present a seminar titled "Prostaglandin Signaling Regulates Male but not Female Lung Host Defense Against P. aeruginosa in Diabetes.”
REDCap MyCap Training
Wednesday, March 12, 2025 10:00am to 11:00am
This is the fifth step in the REDCap training series. In this training, we will discuss using the MyCap mobile app for data collection. We will cover features such as:
Creating participants
Creating tasks and schedules
Active tasks and their unique data output
Direct messages and announcements
This training is a demo and not hands-on. After this training, you will have a basic understanding of the MyCap mobile app for REDCap.
Register by clicking the virtual event link above or by going...
Hardin Open Workshops - PubMed (Zoom)
Wednesday, March 12, 2025 10:00am to 11:00am
This hands-on session will help you improve your searching through best practices for basic and advanced searching and show you features for saving or exporting citations. The session will also help you understand medical subject headings (MeSH) and how they improve your search as well as the benefits of a MyNCBI account.
PLEASE NOTE:
Class will be taught via Zoom. Advance registration is required. Registrants will be emailed the Zoom link 30 minutes before the class time.
Recent Articles from the University of Iowa
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes
Tuesday, March 4, 2025
Heart failure (HF) is a major contributor to global morbidity and mortality. While distinct clinical subtypes, defined by etiology and left ventricular ejection fraction, are well recognized, their genetic determinants remain inadequately understood. In this study, we report a genome-wide association study of HF and its subtypes in a sample of 1.9 million individuals. A total of 153,174 individuals had HF, of whom 44,012 had a nonischemic etiology (ni-HF). A subset of patients with ni-HF were...
Complement is primarily activated in the lung in a mouse model of severe COVID-19
Tuesday, March 4, 2025
In vitro studies and observational human disease data suggest the complement system contributes to SARS-CoV-2 pathogenesis, although how complement dysregulation develops in severe COVID-19 is unknown. Here, using a mouse-adapted SARS-CoV-2 virus (SARS2-N501Y(MA30)) and a mouse model of COVID-19, we identify significant serologic and pulmonary complement activation post-infection. We observed C3 activation in airway and alveolar epithelia, and pulmonary vascular endothelia. Our evidence suggests...
Interim Estimates of 2024-2025 COVID-19 Vaccine Effectiveness Among Adults Aged ≥18 Years - VISION and IVY Networks, September 2024-January 2025
Thursday, February 27, 2025
COVID-19 vaccination averted approximately 68,000 hospitalizations during the 2023-24 respiratory season. In June 2024, CDC and the Advisory Committee on Immunization Practices (ACIP) recommended that all persons aged ≥6 months receive a 2024-2025 COVID-19 vaccine, which targets Omicron JN.1 and JN.1-derived sublineages. Interim effectiveness of 2024-2025 COVID-19 vaccines was estimated against COVID-19-associated emergency department (ED) or urgent care (UC) visits during September 2024-January...
Severe acute respiratory syndrome coronavirus 2 infection unevenly impacts metabolism in the coronal periphery of the lungs
Tuesday, February 25, 2025
SARS-CoV-2, the virus responsible for COVID-19, is a highly contagious virus that can lead to hospitalization and death. COVID-19 is characterized by its involvement in the lungs, particularly the lower lobes. To improve patient outcomes and treatment options, a better understanding of how SARS-CoV-2 impacts the body, particularly the lower respiratory system, is required. In this study, we sought to understand the spatial impact of COVID-19 on the lungs of mice infected with mouse-adapted...
The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation
Friday, February 21, 2025
Cystic fibrosis (CF) is a common autosomal recessive disease resulting from mutations of the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR). Although severe pulmonary neutrophilic inflammation is a primary pathologic feature of CF, more recent studies reveal a role for type 2 inflammation that is characterized by eosinophilia directed by both the innate and adaptive immune systems through ILC2 and CD4^(+) Th2 cells, respectively. We have published that a clear...
K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity
Wednesday, February 19, 2025
CONCLUSION: Nedd4 is a crucial E3 ubiquitin ligase for RORγt in the regulating Th17 cell development and offers potential therapeutic benefits for treating Th17-mediated autoimmune diseases.
Complement activation at the interface between adipocytes and cancer cells drives tumor progression
Tuesday, February 18, 2025
The omentum is the primary site of metastasis for ovarian cancer (OC). Interactions between cancer cells and adipocytes drive an invasive and pro-metastatic phenotype. Here we studied cancer cell-adipocyte crosstalk by using a direct co-culture model with immortalized human visceral pre-adipocytes (VNPAD) and OC cells. We demonstrate increased proliferation, invasiveness, and resistance to cisplatin of co-cultured compared to mono-cultured OC cells. RNA-sequencing of OC cells from co-culture vs....
CF airway epithelia display exaggerated host defense responses and prolonged cilia loss during RSV infection
Sunday, February 16, 2025
CONCLUSIONS: These findings further our understanding of innate immune dysfunction in the CF airway epithelium and suggest that virus-induced cilia injury may further compromise host defenses in CF airways.
TRAF3 is critical for initial T follicular helper cell specification via coordination of the IL-6R/IL-2R-BCL6 signaling nexus
Friday, February 14, 2025
CD4^(+) T follicular helper (T(FH)) cells are essential for orchestrating robust humoral immunity, yet the signals that initiate T(FH) cell differentiation are not fully understood. We identified that the adapter protein TRAF3 was required for T(FH) cell differentiation and function during systemic inflammatory infections. Loss of CD4^(+) T cell-intrinsic TRAF3 impaired chromatin remodeling and transcriptional programming essential for T(FH) cell initiation and instead augmented T(H)1...