Carver College of Medicine Events
Women In Micro & Immuno Coffee Hour
Monday, January 13, 11:00am to Monday, December 8, 2025 12:00pm
Join us for the Women in Micro & Immuno Coffee Hour. It is the monthly coffee hour on the second Monday of the month from 11 a.m. to noon in 1289 CBRB. Enjoy coffee, pastries and contribute to the discussion!
This is open to ALL — students, staff, postdocs, and faculty interested in promoting women in science.
Speakers change monthly. Contact: jessica-tucker@uiowa.edu for details.
Microbiology Undergraduate Student Association (MUSA) Meeting
Sunday, February 2, 2025 4:00pm
Make Connections with people with similar interests!
Molecular Physiology and Biophysics Seminar, Lauren Slosky, PhD
Tuesday, February 4, 2025 9:30am to 10:30am
Dr. Lauren Slosky, an Assistant Professor of Pharmacology at the University of Minnesota will present a seminar titled "In search of addiction therapeutics: Design of allosteric modulators that modify GPCR G protein subtype selectivity."
REDCap Basic Training
Tuesday, February 4, 2025 10:00am to 11:00am
Become familiar with essential basic REDCap features!
Hardin Open Workshops - ORCiD: Open Researcher and Contributor ID (Zoom)
Tuesday, February 4, 2025 12:00pm to 1:00pm
What is ORCID? Why would you want one? This session will discuss ORCID, how researchers can benefit from having one, and how ORCID connects with other information systems. This will also be a hands-on workshop where everyone will have the chance to create their own ORCID and learn the most efficient ways to populate their profile with their publications.
PLEASE NOTE
Class will be taught via Zoom. Advance registration is required. Registrants will be emailed the Zoom link 30 minutes before the...
Recent Articles from the University of Iowa
The circulating plasma microRNA signature in human visceral leishmaniasis
Tuesday, January 28, 2025
Visceral leishmaniasis (VL) is a vector-borne disease caused by the obligate intracellular protozoan Leishmania donovani in India. VL can be complicated by post-kala-azar dermal leishmaniasis (PKDL), a macular or nodular rash that develops in 10%-20% of patients after treatment of VL in India. Patients with PKDL are infectious to sand flies, promoting further transmission of the parasite. MicroRNAs (miRNAs) are 18-25 nt, non-coding RNAs that simultaneously regulate the expression of several or...
Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost
Friday, January 17, 2025
Neutralizing antibody titer has been a surrogate endpoint for guiding COVID-19 vaccine approval and use, although the pandemic's evolution and the introduction of variant-adapted vaccine boosters raise questions as to this surrogate's contemporary performance. For 985 recipients of an mRNA second bivalent or monovalent booster containing various Spike inserts [Prototype (Ancestral), Beta, Delta, and/or Omicron BA.1 or BA.4/5] in the COVAIL trial (NCT05289037), titers against 5 strains were...
The Impact of Cell-Intrinsic STAT6 Protein on Donor T Cell-Mediated Graft-Versus-Tumor Effect
Saturday, January 11, 2025
Bone marrow transplantation (BMT) is mainly performed to restore an anti-tumor immune response, called the graft-versus-tumor (GVT) effect, against leukemia, myeloma and lymphoma. This GVT reactivity is driven by donor T cells, and it can also cause lethal graft-versus-host disease (GVHD). We previously demonstrated that the colonization of mice with helminths preserves the GVT response while suppressing GVHD. As the T helper-2 (Th2) pathway is critical to helminthic immune regulation, we asked...
Epithelial-to-mesenchymal transition and live cell extrusion contribute to measles virus release from human airway epithelia
Friday, January 10, 2025
Measles virus (MeV) is a highly contagious respiratory virus transmitted via aerosols. To understand how MeV exits the airways of an infected host, we use unpassaged primary cultures of human airway epithelial cells (HAE). MeV typically remains cell-associated in HAE and forms foci of infection, termed infectious centers, by directly spreading cell-to-cell. We previously described the phenomenon in which infectious centers detach en masse from HAE and remain viable. Here, we investigate the...
Breast Cancer Susceptibility Gene Sequence Variations and Development of Contralateral Breast Cancer
Thursday, January 9, 2025
CONCLUSIONS AND RELEVANCE: In this case-control study of CBC, deleterious variants in breast cancer susceptibility genes were differentially associated with ER-specific CBC development. Germline variation profile may inform estimates of outcomes for ER-specific CBC subtypes.
Effects of the pan-caspase inhibitor Q-VD-OPh on human neutrophil lifespan and function
Wednesday, January 8, 2025
Human neutrophils are abundant, short-lived leukocytes that turn over at a rate of approximately 1011 cells/day via a constitutive apoptosis program. Certain growth factors, inflammatory mediators and infectious agents can delay apoptosis or induce neutrophils to die by other mechanisms. Nonetheless, a large body of data demonstrates that apoptosis of untreated neutrophils typically ensues within 24 hours of cell isolation and in vitro culture. At the molecular level apoptosis is driven by...
Building a growing genomic repository for maternal and fetal health through the PING Consortium
Friday, January 3, 2025
CONCLUSION: Here, we present the Consortium's formation and overarching study design.
Multiple cell types support productive infection and dynamic translocation of infectious Ebola virus to the surface of human skin
Wednesday, January 1, 2025
Ebola virus (EBOV) causes severe human disease. During late infection, EBOV virions are on the skin's surface; however, the permissive skin cell types and the route of virus translocation to the epidermal surface are unknown. We describe a human skin explant model and demonstrate that EBOV infection of human skin via basal media increases in a time-dependent and dose-dependent manner. In the dermis, cells of myeloid, endothelial, and fibroblast origin were EBOV antigen-positive whereas...
Comparison of ELISA and IFAT for Leishmania infantum by European and Middle Eastern diagnostic laboratories
Sunday, December 29, 2024
CONCLUSIONS: All sites demonstrated substantial comparative diagnostic accuracy, with good agreement based on known seropositive and seronegative samples. Studies and interventional trials that use these tests will remain valid because of high diagnostic agreement between sites.
Immunometabolism in the Aging Heart
Tuesday, December 24, 2024
Structural, functional, and molecular-level changes in the aging heart are influenced by a dynamic interplay between immune signaling and cellular metabolism that is referred to as immunometabolism. This review explores the crosstalk between cellular metabolic pathways including glycolysis, oxidative phosphorylation, fatty acid metabolism, and the immune processes that govern cardiac aging. With a rapidly aging population that coincides with increased cardiovascular risk and cancer incidence...