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Molecular Physiology and Biophysics Seminar, Huan Bao, PhD promotional image

Molecular Physiology and Biophysics Seminar, Huan Bao, PhD

Tuesday, September 30, 2025 9:30am to 10:30am
Bowen Science Building
Neuroscience & Pharmacology Seminar - Tom Reh, PhD promotional image

Neuroscience & Pharmacology Seminar - Tom Reh, PhD

Tuesday, September 30, 2025 10:30am to 11:30am
Medical Education Research Facility
Stimulating retinal regeneration in mammals by reprogramming glia: it’s never too late to change their fateTom Reh, PhDProfessorDepartment of Neurobiology and BiophysicsUniversity of Washington School of Medicine

Department of Microbiology and Immunology Seminar Series

Tuesday, September 30, 2025 3:00pm to 4:00pm
Bowen Science Building
Seminar Series
Documentary premiere: Breath by Breath promotional image

Documentary premiere: Breath by Breath

Tuesday, September 30, 2025 3:30pm to 5:00pm
Medical Education Research Facility
Cystic fibrosis was considered a long road in a life cut short. That's changing.
Breath by Breath: Living with Cystic Fibrosis promotional image

Breath by Breath: Living with Cystic Fibrosis

Tuesday, September 30, 2025 4:00pm to 5:00pm
Virtual
Documentary livestream premiere
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Recent Articles from the University of Iowa

Ebola virus' hidden target: virus transmission to and infection of skin

Friday, September 12, 2025
Paige T Richards
Ebola virus (EBOV), the causative agent of Ebola virus disease, remains one of the World Health Organization's top 10 threats to global health. Infectious EBOV virions can be found on the surface of skin late in infection and may be transmitted to others through skin-to-skin contact. We investigate in vivo EBOV tropism and the kinetics of virus movement to and from the skin. Increasing viral loads were detected over time in the skin of EBOV-infected non-human primates and mice, with antigen...

Identification of proteins in semen-derived extracellular vesicles that bind to Tat and NF-κB and that may impair HIV replication

Tuesday, September 9, 2025
Bryson C Okeoma
Replication of HIV-1 requires the coordinated action of host and viral transcription factors, most critically the viral transactivator Tat and the host nuclear factor κB (NF-κB). This activity is disrupted in infected cells that are cultured with extracellular vesicles (EVs) present in human semen, suggesting that they contain factors that could inform the development of new therapeutics. Here, we explored the contents of semen-derived EVs (SEVs) from uninfected donors and individuals with HIV-1...

FABP5 in skin macrophages mediates saturated fat-induced IL-1β signaling in psoriatic inflammation

Saturday, September 6, 2025
Jianyu Yu
High fat diet (HFD)-induced obesity increases the risk and severity of psoriasis. However, the immunoregulatory effects of different HFDs on psoriasis pathogenesis remains poorly understood. Here, mimicking human dietary fat profiles, four HFDs-saturated, monounsaturated, omega-6, and omega-3 fats-were designed and used to induce obesity in mice. Despite comparable obesity levels across groups, only the saturated HFD exacerbated imiquimod (IMQ)-induced psoriasis. This exacerbation correlated...

Pancancer outcome prediction via a unified weakly supervised deep learning model

Tuesday, September 2, 2025
Wei Yuan
Accurate prognosis prediction is essential for guiding cancer treatment and improving patient outcomes. While recent studies have demonstrated the potential of histopathological images in survival analysis, existing models are typically developed in a cancer-specific manner, lack extensive external validation, and often rely on molecular data that are not routinely available in clinical practice. To address these limitations, we present PROGPATH, a unified model capable of integrating...

Growth inhibition of common neonatal pathogens differs between bovine lactoferrin products

Friday, August 29, 2025
Kyra P Watral
Introduction. Infection is a leading cause of mortality during the first year of life, with the neonatal period being particularly high risk. It is critical to identify non-antibiotic approaches to improve neonatal infection outcomes due to the non-specific clinical signs of neonatal infection and negative consequences of early-life antibiotic exposure. Lactoferrin is a protein found in all mammalian milk that has a variety of antimicrobial properties. Clinical trials have shown that lactoferrin...

Mechanistic insights into the small-molecule inhibition of influenza A virus entry

Wednesday, August 13, 2025
Yan Xu
Influenza A virus (IAV) is a zoonotic pathogen responsible for seasonal and pandemic flu. The extensive genetic and antigenic diversity within and between IAV phylogenetic groups presents major challenges for developing universal vaccines and broad-spectrum antiviral therapies. Current interventions provide limited protection due to the virus's high mutation rate and capacity for immune evasion. Recent advancements in viral hemagglutinin (HA)-targeting small-molecule entry inhibitors offer a...

Treatment of Persons with Rheumatoid Arthritis with a History of Cancer

Monday, August 11, 2025
Beeta Shasti-Nazem
PURPOSE OF REVIEW: This review article examines the evolving evidence on cancer recurrence and new malignancy risk associated with disease-modifying antirheumatic drugs (DMARDs), including TNF inhibitors, rituximab, IL-6 inhibitors, and JAK inhibitors, in patients with rheumatoid arthritis and a prior malignancy.

Effective Aerosol Inoculation of Dose-Escalated Seasonal Influenza H3N2 Virus in Controlled Human Infection Model

Friday, August 8, 2025
Nadine Rouphael
Human challenge models (CHIMs) are instrumental in advancing influenza research but have traditionally relied on intranasal inoculation, which does not mimic the natural aerosol transmission of the virus. We conducted a dose-escalation influenza CHIM study to evaluate the safety and feasibility of two modern aerosol delivery systems: a flow-focusing monodisperse aerosol generator (FMAG) and a medical nebulizer. Fourteen healthy adults aged 18-49 years were exposed to influenza A/Perth/16/2009...

A versatile H5N1-VSV platform for safe influenza virus research applications

Friday, August 8, 2025
Boopathi Sownthirarajan
The H5N1 strain of influenza A virus (IAV) continues to cause severe infections in a range of avian and mammalian species, including sporadic but concerning cases in humans. There is growing concern that circulating H5N1 strains could lead to widespread human outbreaks. Research with highly pathogenic H5N1 viruses is restricted to Biosafety Level 3 (BSL-3) laboratories. Vesicular stomatitis virus (VSV)-based vaccine vectors expressing heterologous viral proteins from Ebola, SARS-CoV-2, Lassa...

Palmitate enhances MSC immunomodulation of human macrophages via the ceramide/CCL2 axis in vitro

Thursday, August 7, 2025
Courteney Tunstead
CONCLUSION: Palmitate-exposed MSCs show enhanced immunomodulation of human MDMs, through the ceramide/CCL2 axis in vitro.