Carver College of Medicine Events
Molecular Medicine Interdisciplinary Program Thesis Defense Seminar: Sandra Blom
Friday, June 6, 2025 1:00pm
Sandra Blom is a PhD candidate in the Biomedical Science (Molecular Medicine) Interdisciplinary Graduate Program. Her research has been with Dr. Samuel Stephens's laboratory.If you are unable to attend in person, please consider showing support via Zoom: https://uiowa.zoom.us/j/93210709435
Women In Micro & Immuno Coffee Hour
Monday, June 9, 2025 11:00am to 12:00pm
Join us for the Women in Micro & Immuno Coffee Hour. It is the monthly coffee hour on the second Monday of the month from 11 a.m. to noon in 1289 CBRB. Enjoy coffee, pastries and contribute to the discussion!This is open to ALL — students, staff, postdocs, and faculty interested in promoting women in science.Speakers change monthly. Contact: jessica-tucker@uiowa.edu for details.
Hardin Open Workshops - EndNote Desktop (Zoom)
Tuesday, June 10, 2025 10:00am to 11:00am
EndNote is a reference management tool that helps you to easily gather together your references in one place, organize them, and then insert them into papers and format them in a style of your choosing. This session will walk you through the basics of using EndNote to collect and format your citations. The class will be hands-on, and there will be time for questions at the end.PLEASE NOTEClass will be taught via Zoom. Advance registration is required. Registrants will be emailed the Zoom link 30...
REDCap Basic Training
Tuesday, June 10, 2025 10:00am to 11:00am
This is the first step in the REDCap training series. In this training, we will build a new REDCap project from scratch and cover basic features such as:
• Building forms with proper field types and validation
• Assigning user permissions
• Project backup and overview with data dictionary, codebook, pdf, and xml
• Ensuring your project works properly by testing with real world application
• Making mid-study modifications safely after having started data collection in production
• Creating...
TriNetX Basic Training
Tuesday, June 10, 2025 2:00pm to 3:00pm
This training will provide an in-depth look at TriNetX and show you how to use the tool. We will go through building a study, searching for a specific population, and finally what information you can gather from the specific cohort. We will also discuss next steps on getting data extracted for research.
After this training you will have a thorough understanding of how to use TriNetX and what the process is to get data extracted for research studies.
Register by clicking the virtual event link...
Recent Articles from the University of Iowa
Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy
Monday, June 2, 2025
INTRODUCTION: Dysregulation of the alternative pathway of complement underlies the pathogenesis of C3 glomerulopathy (C3G). Because Factor H (FH) prevents excessive alternative pathway activity while Factor H-related protein 1 (FHR-1) is believed to enhance this response, we investigated the balance between FH and FHR-1 in C3G.
Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs
Friday, May 30, 2025
Transfer RNAs (tRNAs) are fundamental for both cellular and viral gene expression during viral infection. In addition, mounting evidence supports the biological function for tRNA cleavage products, including the control of gene expression during conditions of stress and infection. We previously reported that infection with the model murine gammaherpesvirus 68, MHV68, leads to enhanced tRNA transcription. However, whether this has any influence on tRNA transcript processing, viral replication, or...
Naturally transmitted mouse viruses highlight the heterogeneity of virus transmission dynamics in the dirty mouse model
Wednesday, May 28, 2025
Specific-pathogen-free (SPF) mice are widely used in biomedical research to model human infections. However, these animals do not always accurately recapitulate human immune responses. This is due, in part, to their lack of infection history. A growing number of studies show that the host microbiome influences the development, progression, and responses of many diseases. To date, the majority of research on the microbiome has focused on the bacterial populations and less on the eukaryotic virome...
WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity
Wednesday, May 28, 2025
Tissue-resident macrophages (TRM) are critical for mammalian organismal development and homeostasis. Here we report that with-no-lysine 1 (WNK1) controls myeloid progenitor fate, with Csf1r^(iCre)-mediated Wnk1 deletion in mice (WNK1-deficient mice) resulting in loss of TRMs and causing perinatal mortality. Mechanistically, absence of WNK1 or inhibition of WNK kinase activity disrupts macrophage colony-stimulating factor (M-CSF)-stimulated macropinocytosis, thereby blocking mouse and human...
Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021
Friday, May 23, 2025
CONCLUSIONS AND RELEVANCE: Although the global age-standardized burden rates of SAH more than halved over the last 3 decades, SAH remained one of the most common cardiovascular and neurological causes of death and disabilities in the world, with increasing absolute case numbers. These findings suggest evidence for the potential health benefits of proactive public health planning and resource allocation toward the prevention of SAH.
Mutation in Staphylococcus aureus that supports gain of function in susceptibility both to hypochlorous acid and to human neutrophils
Monday, May 19, 2025
Optimal antimicrobial action of human neutrophils (PMN) relies on the synergy of oxidants and granule proteins, most notably that between the granule protein myeloperoxidase (MPO) and hydrogen peroxide (H2O2) to oxidize chloride anion to produce the potent microbicide, hypochlorous acid (HOCl). However, despite the potency of HOCl, some ingested Staphylococcus aureus cells survive within PMN and contribute to disease. To identify factors that support the resistance of ingested staphylococci to...
Protocol for supervised automation of cell counting in confocal microscopic mice cochlear imaging datasets using macro in Imaris
Saturday, May 17, 2025
Analyzing confocal microscopic data using Imaris is time-consuming and prone to human error. We present a supervised automation protocol to reduce manual input for cell and spot counting in confocal images of mouse cochlear sections. The protocol includes installing Imaris; preparing confocal images for Imaris; applying the image recognition tool in Macro Scheduler to create surfaces, masks, and spots; and using batch processing to analyze groups of images efficiently. This approach improves...
Recombinant Adeno-Associated Virus Vector Mediated Gene Editing in Proliferating and Polarized Cultures of Human Airway Epithelial Cells
Tuesday, May 13, 2025
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. While CRISPR-based CFTR editing approaches have shown proof-of-concept for functional rescue in primary airway basal cells, induced pluripotent stem cells, and organoid cultures derived from patients with CF, their efficacy remains suboptimal. Here, we developed the CuFi^(Cas9(Y66S)eGFP) reporter system by integrating spCas9 and a non-fluorescent Y66S eGFP mutant into CuFi-8 cells,...
Characterization of serotype-specific Dengue virus T cell inhibition
Thursday, May 8, 2025
CONCLUSIONS: DENV-2 and -3 are associated with more severe clinical disease than DENV-1 and -4; however, no biological explanation for this difference has been previously identified. We found that DENV-1 and -4 viral particles and env proteins blunt T cell responses by interfering with proximal TCR signaling while DENV-2 and -3 do not, potentially explaining DENV pathogenic outcomes in primary and secondary infection.
HLA DQA1*05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children With Crohn's Disease
Friday, May 2, 2025
INTRODUCTION: Human leukocyte antigen (HLA) DQA1*05 has been associated with the development of anti-drug antibodies (ADA) to tumor necrosis factor antagonists (anti-TNFα) and treatment failure among adults with Crohn's disease (CD). However, findings from other studies have been inconsistent with limited pediatric data.